Title:
ヒスタミンH3アンタゴニストとして有用なイミダゾールおよびベンゾイミダゾール誘導体
Document Type and Number:
Japanese Patent JP2008526895
Kind Code:
A
Abstract:
Disclosed are compounds of the formula or a pharmaceutically acceptable salt or solvate thereof, wherein: n is 2-5; R is R3-aryl, R3-heteroaryl, R3-cycloalkyl, R3-heterocycloalkyl, alkyl, haloalkyl, -OR4, -SR4 or -S(O)1-2R5; R1 and R2 are H or optionally substituted phenyl or optionally substituted and X is -O- or -S-; or R1 and R2, together with the carbon atoms to which they are attached form optionally substituted and X is -O-, -S- or -NR7-; Z is and the remaining variables are as defined in the specification; also disclosed are pharmaceutical compositions comprising the compounds of formula I; also disclosed are methods of treating allergy, allergy-induced airway responses, congestion, obesity and metabolic syndrome using the compounds of Formula I, as well as combinations with other drugs useful for treating those diseases.
Inventors:
Aslanian, Robert G.
Tom, Wing Sea.
Ju, Xiao Hong
Tom, Wing Sea.
Ju, Xiao Hong
Application Number:
JP2007550589A
Publication Date:
July 24, 2008
Filing Date:
January 19, 2006
Export Citation:
Assignee:
Schering Corporation
International Classes:
C07D233/84; A61K31/4439; A61K31/454; A61K31/4545; A61K31/4725; A61K31/473; A61K31/496; A61K31/506; A61K31/5377; A61K31/541; A61K31/55; A61K31/5513; A61P1/04; A61P3/04; A61P9/02; A61P9/10; A61P11/02; A61P25/00; A61P25/06; A61P25/18; A61P25/20; A61P25/28; A61P37/08; A61P43/00; C07D235/28; C07D401/04; C07D401/14; C07D405/14; C07D413/14; C07D417/14; C07D491/113
Foreign References:
| WO2003088967A1 | 2003-10-30 | |||
| WO2003080610A1 | 2003-10-02 |
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita