Title:
METHOD FOR RECONSTRUCTING IMMUNE FUNCTION USING PLURIPOTENT STEM CELLS
Document Type and Number:
Japanese Patent JP2018038409
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide a method for producing a human T cell and a method for cell-based immunotherapy which can be used for supplementation or regeneration of immune function, which becomes effective tools in ameliorating pathological conditions of and improving the effect of treatment of diseases.SOLUTION: The present invention provides a method which comprises the steps of inducing an iPS cell from a human T cell, and differentiating the iPS cell into a T cell, the produced human T cell retaining the TCR gene rearrangement pattern of the original human T lymphocytes. The present invention also provides a pharmaceutical composition comprising the T cell produced by the method; and a method for cell-based immunotherapy using the method.SELECTED DRAWING: None
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Inventors:
NAKAUCHI HIROMITSU
KANEKO ARATA
NISHIMURA TOSHINOBU
KANEKO ARATA
NISHIMURA TOSHINOBU
Application Number:
JP2017194948A
Publication Date:
March 15, 2018
Filing Date:
October 05, 2017
Export Citation:
Assignee:
UNIV TOKYO
International Classes:
C12N5/0783; A61K35/17; A61P37/02; A61K35/12
Foreign References:
| WO2011096482A1 | 2011-08-11 | |||
| WO2008143255A1 | 2008-11-27 | |||
| WO2009157593A1 | 2009-12-30 |
Other References:
J.IMMUNOL., vol. 182(11), JPN6015013658, 2009, pages 6879 - 6888, ISSN: 0003905456
PROC. NATL. ACAD. SCI. U.S.A., vol. 103(31), JPN6015013660, 2006, pages 11742 - 11747, ISSN: 0003905457
PROC. NATL. ACAD. SCI. U.S.A., vol. 103(31), JPN6015013660, 2006, pages 11742 - 11747, ISSN: 0003905457
Attorney, Agent or Firm:
Seiji Ohno
Hiroshi Morita
Hiroshi Morita