IMMUNE REGULATION BASED ON TARGETING OF EARLY ACTIVATION MOLECULE

Japanese Patent JP2010229156

A

To provide a specific antibody for targeting of such a molecule in treating of a disease concerning the presence of an activation cell which expresses one or more of CD69, AICL and LLT1.

A method of treating subjects having disorders or conditions characterized by an unwanted immune response is disclosed. The method includes a step of administering an effective amount of an early activation molecule agonist, antagonist or depletor to the subject. A human monoclonal antibody specific to the early activation molecule and a method of use are also disclosed. The invention is based on finding that can partially regulate a target immune response using regulation of CD69, AICL and/or LLT1 and accordingly can be used for treatment of various disorders.

SANCHEZ-MADRID FRANCISCO
ALONSO CARLOS MARTINEZ
MADRID DAVID SANCHO
ROCAMORA PABLO ENGEL
ARTOLA ENRIC ESPLUGUES
RAMOS JAVIER VEGA
GOMEZ PILAR LAUZURICA

JP2010142101A

October 14, 2010

June 22, 2010

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ALBOR BIOLOG INC

A61K45/00; A61K39/00; A61K39/395; A61P1/00; A61P1/04; A61P1/16; A61P1/18; A61P3/10; A61P9/00; A61P9/10; A61P11/00; A61P11/06; A61P13/12; A61P17/00; A61P17/06; A61P21/04; A61P25/00; A61P27/16; A61P29/00; A61P35/00; A61P37/00; A61P37/02; A61P37/06; A61P37/08; C07K14/705; C07K16/28; G01N33/53; G01N33/577; A61K

JPN6010009525; Ｓｃａｎｄｉｎａｖｉａｎ　Ｊｏｕｒｎａｌ　ｏｆ　Ｉｍｍｕｎｏｌｏｇｙ Ｖｏｌ．５６，Ｎｏ．４, 2002, ｐ４１７-４２８
JPN6010009526; Ｂｌｏｏｄ Ｖｏｌ．８７，Ｎｏ．７, 1996, ｐ２８１５-２８２１
JPN6010009527; Ｊｏｕｒｎａｌ　ｏｆ　Ｅｘｐｅｒｉｍｅｎｔａｌ　Ｍｅｄｉｃｉｎｅ Ｖｏｌ．１７４，Ｎｏ．６, 1991, ｐ１３９３-１３９８
JPN6010009529; Ｅｕｒｏｐｅａｎ　Ｊｏｕｒｎａｌ　ｏｆ　Ｉｍｍｕｎｏｌｏｇｙ Ｖｏｌ．３０，Ｎｏ．２, 2000, ｐ６４４-６５１
JPN6010009531; Ｊｏｕｒｎａｌ　ｏｆ　Ｅｘｐｅｒｉｍｅｎｔａｌ　Ｍｅｄｉｃｉｎｅ Ｖｏｌ．１８０，Ｎｏ．５, 1994, ｐ１９９９-２００４

Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita

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