IMPROVEMENT OF ORGANIC COMPOUND

Japanese Patent JPS51125060

A

1500063 2-Indolinone and fluorenone derivatives SANDOZ Ltd 16 June 1975 [19 June 1974 (2)] 25530/75 Heading C2C Novel 2-indolinone and fluorenone derivatives of the general formula wherein Het is a radical formed by removing a hydrogen atom from the phenyl ring of 2-indolinone or fluorenone, and R is a group having one of the following Formulµ A, B, C and D in which n is 2 or 3, n1 is 1-4, X-X1 is ethylene or vinylene and in D the two C atoms adjacent to the N atom are identically unsubstituted or substituted by one or two C 1-4 alkyl groups and acid addition salts thereof are prepared by reacting Het-O-CH 2 -CH(OH)-CH 2 Y, in which Y is a leaving group, or an epoxy compound of the general Formula IIa with H-R, followed optionally by salification of the product. Pharmaceutical compositions having antiarrhythmic activity comprise, as active ingredient, a 2-indolinone or fluorenone derivative (I) or a pharmaceutically acceptable acid addition salt thereof, in association with a pharmaceutical carrier or diluent.

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BERUTOHORUDO RICHIYAADO
TOROKUTSUSURAA FURANTSU

JP7328075A

November 01, 1976

June 18, 1975

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SANDOZ AG

A61K31/015; A61K31/403; A61K31/404; C07D203/10; C07D205/04; C07D209/34; C07D211/14; C07D213/73; C07D239/42; C07D295/08; C07D295/088; C07D317/18; C07D401/12; C07D403/12; C07D451/02; C07D451/14; (IPC1-7): C07D295/08; C07D213/73; C07D239/42; C07D451/02; C07D451/14; C07D401/12; C07D403/12

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