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Title:
INDUSTRIAL PRODUCTION OF 1,3-THIAZOLIDIN-2-ONE
Document Type and Number:
Japanese Patent JP2001048870
Kind Code:
A
Abstract:

To produce highly pure 1,3-thiazolidin-2-one by using an easily available inexpensive raw material by a simple method by reacting ethanol amine with hydrogen chloride, and further reacting the product with carbonyl sulfide without purifying the product.

(i) Ethanolamine is reacted with hydrogen chloride to provide 2-chloroethylamine hydrochloride, and (ii) water is added to the obtained 2- chloroethylamine hydrochloride without purifying the 2-chloroethylamine hydrochloride. The obtained mixture is subjected to filtration to remove a solid component, and the filtrate is reacted with carbonyl sulfide in the presence of a base (e.g. sodium hydroxide) to provide the objective 1,3-thiazolidin-2-one. The reaction of (i) is preferably carried out in the presence of a solid acid catalyst (e.g. zeolite). Preferably, the hydrogen chloride of 1 eq. is blown into the ethanolamine at 90-110°C, and further 1-6 eq. thereof is blown thereinto after the temperature is raised to 140-180°C. The reaction of (ii) is preferably carried out by using a secondary alcohol (e.g. 2-propanol) as a solvent. After finishing the reaction, the objective product is extracted by adding 1-butanol or the like.


Inventors:
KIMURA YOSHIICHI
KUDO FUMIYUKI
Application Number:
JP22746799A
Publication Date:
February 20, 2001
Filing Date:
August 11, 1999
Export Citation:
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Assignee:
IHARA CHEMICAL IND CO
International Classes:
C07D277/20; B01J21/16; B01J29/04; C07B61/00; C07D277/34; (IPC1-7): C07D277/34; B01J21/16; B01J29/04