INHIBITOR OF THE MUTANT FORM OF KIT

Title:

INHIBITOR OF THE MUTANT FORM OF KIT

Document Type and Number:

Japanese Patent JP2011121973

Kind Code:

A

Abstract:

To provide inhibitors of mutant KIT effective even for KIT (a receptor protein tyrosine kinase) dependent diseases which are resistant to treatment with imatinib.

The present invention relates to the use of an appropriate inhibitor of mutant KIT for the manufacture of a medicament for treating a KIT dependent disease in a patient, selected from the group consisting of midostaurin, vatalanib, and a compound of formula (A).

Inventors:

BUCHDUNGER ELISABETH
FABBRO DORIANO

Application Number:

JP2011020873A

Publication Date:

June 23, 2011

Filing Date:

February 02, 2011

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Assignee:

NOVARTIS AG

International Classes:

A61K31/553; A61K31/502; A61K31/506; A61P3/04; A61P35/00; A61P43/00; C07D498/22

Other References:

JPN6013002312; ＧＩＬＬＩＬＡＮＤ，　Ｄ．Ｇ．　ｅｔ　ａｌ．: Ｈｏｗａｒｄ　Ｈｕｇｈｅｓ　Ｍｅｄｉｃａｌ　Ｉｎｓｔｉｔｕｔｅ , 20030520, ｐ．１-３
JPN6013002316; Ｃａｎｃｅｒ　ＣｅｌｌＶｏｌ．３, 20030520, ｐ．４５９-４６９
JPN6013002329; ＢｌｏｏｄＶｏｌ．１０２，　Ｎｏ．１１, 20031116, ９１９ａ，　Ａｂｓｔｒａｃｔ＃３４２０
JPN6013002333; Ｃａｎｃｅｒ　ＣｅｌｌＶｏｌ．１, 2002, ｐ．４３３-４４３
JPN6013002337; ＢｌｏｏｄＶｏｌ．１０２，　Ｎｏ１１, 20031116, ５９４ａ，Ａｂｓｔｒａｃｔ＃２１９０
JPN6013002340; ＢｌｏｏｄＶｏｌ．１０２，　Ｎｏ．１１, 20031116, ６１４ａ，Ａｂｓｔｒａｃｔ＃２２７０
JPN6013002322; Ｃａｎｃｅｒ　ＣｅｌｌＶｏｌ．３, 200302, ｐ．１７３-１８３
JPN6013002327; ＢｌｏｏｄＶｏｌ．１０２，　Ｎｏ．２, 20030715, ｐ．６４６-６５１

Attorney, Agent or Firm:

Mitsuo Tanaka
Hiroshi Yamazaki
Kenji Tomita
Mina Shiga
Masayuki Nakagawa

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