Title:
INHIBITOR OF TYROSINE KINASE
Document Type and Number:
Japanese Patent JP2011219495
Kind Code:
A
Abstract:
To provide a novel compound exhibiting inhibition of protein kinase activity; a method for producing the compound; a pharmaceutical composition containing the compound; and the use of the compound or the pharmaceutical composition.
There are provided: a compound represented by formula (1); a method for producing the compound; a pharmaceutical composition containing the compound; the use thereof optionally in combination with one or more other pharmaceutically active compounds for the therapy of a disease which responds to an inhibition of protein kinase activity, especially a neoplastic disease, in particular leukemia; and a method for the treatment of such diseases.
Inventors:
BREITENSTEIN WERNER
FURET PASCAL
JACOB SANDRA
MANLEY PAUL WILLIAM
FURET PASCAL
JACOB SANDRA
MANLEY PAUL WILLIAM
Application Number:
JP2011153046A
Publication Date:
November 04, 2011
Filing Date:
July 11, 2011
Export Citation:
Assignee:
NOVARTIS AG
International Classes:
C07D401/04; A61K31/506; A61K31/5377; A61K31/55; A61P35/00; A61P35/02; A61P43/00; C07D401/10; C07D401/14; C07D405/14; C07D413/14; C07D417/14; A61P3/10; A61P9/00; A61P9/10; A61P11/06; A61P13/12; A61P15/08; A61P17/06; A61P27/02; A61P35/04; A61P37/06
Domestic Patent References:
| JP2005533827A | 2005-11-10 | |||
| JPH06184116A | 1994-07-05 | |||
| JPH08504215A | 1996-05-07 | |||
| JP2005533827A | 2005-11-10 | |||
| JPH06184116A | 1994-07-05 | |||
| JPH08504215A | 1996-05-07 | |||
| JP4110140B2 | 2008-07-02 |
Other References:
JPN7007002317; ＪＩＭＭＥＲＭＡＮＮ Ｊ: 'Ｐｏｔｅｎｔ ａｎｄ ｓｅｌｅｃｔｉｖｅ ｉｎｈｉｂｉｔｏｒｓ ｏｆ ｔｈｅ Ａｂｌ-ｋｉｎａｓｅ：ｐｈｅｎｙｌａｍｉｎｏ-ｐｙｒｉｍｉｄｉｎｅ（ＰＡＰ）ｄｅｒｉｖａｔｉｖｅｓ' ＢＩＯＯＲＧＡＮＩＣ ＆ ＭＥＤＩＣＩＮＡＬ ＣＨＥＭＩＳＴＲＹ ＬＥＴＴＥＲＳ Ｖｏｌ．７， Ｎｏ．２, 19970121, ｐｐ．１８７-１９２
JPN7007002318; ＪＩＭＭＥＲＭＡＮＮ Ｊ: 'Ｐｈｅｎｙｌａｍｉｎｏ-ｐｙｒｉｍｉｄｉｎｅ（ＰＡＰ）ｄｅｒｉｖａｔｉｖｅｓ：ａ ｎｅｗ ｃｌａｓｓ ｏｆ ｐｏｔｅｎｔ ａｎｄ ｈｉｇｈｌｙ ｓｅｌｅｃｔｉｖｅ ＰＤＧＦ-ｒｅｃｅｐｔｏｒ ａｕｔｏ' ＢＩＯＯＲＧＡＮＩＣ ＆ ＭＥＤＩＣＩＮＡＬ ＣＨＥＭＩＳＴＲＹ ＬＥＴＴＥＲＳ Ｖｏｌ．６， Ｎｏ．１１, 19960604, ｐｐ．１２２１-１２２６
JPN7007002319; ＰＡＵＬ Ｒ: 'Ｐｒｅｐａｒａｔｉｏｎ ｏｆ ｓｕｂｓｔｉｔｕｔｅｄ Ｎ-ｐｈｅｎｙｌ-４-ａｒｙｌ-２-ｐｙｒｉｍｉｄｉｎａｍｉｎｅｓ ａｓ ｍｅｄｉａｔｏｒ ｒｅｌｅａｓｅ ｉｎｈｉｂｉｔｏｒｓ' ＪＯＵＲＮＡＬ ＯＦ ＭＥＤＩＣＩＮＡＬ ＣＨＥＭＩＳＴＲＹ Ｖｏｌ．３６， Ｎｏ．１９, 19930917, ｐｐ．２７１６-２７２５
JPN7007002317; ＪＩＭＭＥＲＭＡＮＮ Ｊ: 'Ｐｏｔｅｎｔ ａｎｄ ｓｅｌｅｃｔｉｖｅ ｉｎｈｉｂｉｔｏｒｓ ｏｆ ｔｈｅ Ａｂｌ-ｋｉｎａｓｅ：ｐｈｅｎｙｌａｍｉｎｏ-ｐｙｒｉｍｉｄｉｎｅ（ＰＡＰ）ｄｅｒｉｖａｔｉｖｅｓ' ＢＩＯＯＲＧＡＮＩＣ ＆ ＭＥＤＩＣＩＮＡＬ ＣＨＥＭＩＳＴＲＹ ＬＥＴＴＥＲＳ Ｖｏｌ．７， Ｎｏ．２, 19970121, ｐｐ．１８７-１９２
JPN7007002318; ＪＩＭＭＥＲＭＡＮＮ Ｊ: 'Ｐｈｅｎｙｌａｍｉｎｏ-ｐｙｒｉｍｉｄｉｎｅ（ＰＡＰ）ｄｅｒｉｖａｔｉｖｅｓ：ａ ｎｅｗ ｃｌａｓｓ ｏｆ ｐｏｔｅｎｔ ａｎｄ ｈｉｇｈｌｙ ｓｅｌｅｃｔｉｖｅ ＰＤＧＦ-ｒｅｃｅｐｔｏｒ ａｕｔｏ' ＢＩＯＯＲＧＡＮＩＣ ＆ ＭＥＤＩＣＩＮＡＬ ＣＨＥＭＩＳＴＲＹ ＬＥＴＴＥＲＳ Ｖｏｌ．６， Ｎｏ．１１, 19960604, ｐｐ．１２２１-１２２６
JPN7007002319; ＰＡＵＬ Ｒ: 'Ｐｒｅｐａｒａｔｉｏｎ ｏｆ ｓｕｂｓｔｉｔｕｔｅｄ Ｎ-ｐｈｅｎｙｌ-４-ａｒｙｌ-２-ｐｙｒｉｍｉｄｉｎａｍｉｎｅｓ ａｓ ｍｅｄｉａｔｏｒ ｒｅｌｅａｓｅ ｉｎｈｉｂｉｔｏｒｓ' ＪＯＵＲＮＡＬ ＯＦ ＭＥＤＩＣＩＮＡＬ ＣＨＥＭＩＳＴＲＹ Ｖｏｌ．３６， Ｎｏ．１９, 19930917, ｐｐ．２７１６-２７２５
JPN7007002318; ＪＩＭＭＥＲＭＡＮＮ Ｊ: 'Ｐｈｅｎｙｌａｍｉｎｏ-ｐｙｒｉｍｉｄｉｎｅ（ＰＡＰ）ｄｅｒｉｖａｔｉｖｅｓ：ａ ｎｅｗ ｃｌａｓｓ ｏｆ ｐｏｔｅｎｔ ａｎｄ ｈｉｇｈｌｙ ｓｅｌｅｃｔｉｖｅ ＰＤＧＦ-ｒｅｃｅｐｔｏｒ ａｕｔｏ' ＢＩＯＯＲＧＡＮＩＣ ＆ ＭＥＤＩＣＩＮＡＬ ＣＨＥＭＩＳＴＲＹ ＬＥＴＴＥＲＳ Ｖｏｌ．６， Ｎｏ．１１, 19960604, ｐｐ．１２２１-１２２６
JPN7007002319; ＰＡＵＬ Ｒ: 'Ｐｒｅｐａｒａｔｉｏｎ ｏｆ ｓｕｂｓｔｉｔｕｔｅｄ Ｎ-ｐｈｅｎｙｌ-４-ａｒｙｌ-２-ｐｙｒｉｍｉｄｉｎａｍｉｎｅｓ ａｓ ｍｅｄｉａｔｏｒ ｒｅｌｅａｓｅ ｉｎｈｉｂｉｔｏｒｓ' ＪＯＵＲＮＡＬ ＯＦ ＭＥＤＩＣＩＮＡＬ ＣＨＥＭＩＳＴＲＹ Ｖｏｌ．３６， Ｎｏ．１９, 19930917, ｐｐ．２７１６-２７２５
JPN7007002317; ＪＩＭＭＥＲＭＡＮＮ Ｊ: 'Ｐｏｔｅｎｔ ａｎｄ ｓｅｌｅｃｔｉｖｅ ｉｎｈｉｂｉｔｏｒｓ ｏｆ ｔｈｅ Ａｂｌ-ｋｉｎａｓｅ：ｐｈｅｎｙｌａｍｉｎｏ-ｐｙｒｉｍｉｄｉｎｅ（ＰＡＰ）ｄｅｒｉｖａｔｉｖｅｓ' ＢＩＯＯＲＧＡＮＩＣ ＆ ＭＥＤＩＣＩＮＡＬ ＣＨＥＭＩＳＴＲＹ ＬＥＴＴＥＲＳ Ｖｏｌ．７， Ｎｏ．２, 19970121, ｐｐ．１８７-１９２
JPN7007002318; ＪＩＭＭＥＲＭＡＮＮ Ｊ: 'Ｐｈｅｎｙｌａｍｉｎｏ-ｐｙｒｉｍｉｄｉｎｅ（ＰＡＰ）ｄｅｒｉｖａｔｉｖｅｓ：ａ ｎｅｗ ｃｌａｓｓ ｏｆ ｐｏｔｅｎｔ ａｎｄ ｈｉｇｈｌｙ ｓｅｌｅｃｔｉｖｅ ＰＤＧＦ-ｒｅｃｅｐｔｏｒ ａｕｔｏ' ＢＩＯＯＲＧＡＮＩＣ ＆ ＭＥＤＩＣＩＮＡＬ ＣＨＥＭＩＳＴＲＹ ＬＥＴＴＥＲＳ Ｖｏｌ．６， Ｎｏ．１１, 19960604, ｐｐ．１２２１-１２２６
JPN7007002319; ＰＡＵＬ Ｒ: 'Ｐｒｅｐａｒａｔｉｏｎ ｏｆ ｓｕｂｓｔｉｔｕｔｅｄ Ｎ-ｐｈｅｎｙｌ-４-ａｒｙｌ-２-ｐｙｒｉｍｉｄｉｎａｍｉｎｅｓ ａｓ ｍｅｄｉａｔｏｒ ｒｅｌｅａｓｅ ｉｎｈｉｂｉｔｏｒｓ' ＪＯＵＲＮＡＬ ＯＦ ＭＥＤＩＣＩＮＡＬ ＣＨＥＭＩＳＴＲＹ Ｖｏｌ．３６， Ｎｏ．１９, 19930917, ｐｐ．２７１６-２７２５
Attorney, Agent or Firm:
Aoyama Aoi
Takuji Yamada
Michiko Matsutani
Mitsutaka Iwasaki
Yasushi Ochiai
Takuji Yamada
Michiko Matsutani
Mitsutaka Iwasaki
Yasushi Ochiai