Title:
INTERMEDIATE FOR ENZYME INHIBITOR
Document Type and Number:
Japanese Patent JP3614711
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To obtain a new compound useful for a production intermediate compound of a selective inhibitor for an inducible nitric-oxide synthase.
SOLUTION: This compound is expressed by formula I (Q is H or a carboxy protecting group; Q' is a protecting group), preferably, t-butyl-6- benzyloxycarbonylamino-2-t-butoxycarbonylamino-4,4-dioxy-4-thiahexanoate. The compound of formula I is obtained, for example, by oxidizing a compound of formula II (p is 2 or 3; q is 1 or 2; Q" is a protecting group) [for example; S-(2-benzyloxycarbonylamino)-N-butyloxycarbonylcysteine tert-butyl ester or the like], in a solvent such as methanol or the like with oxone or the like, and removing the protecting group Q" under the condition of catalytic transfer hydrogenation.
Inventors:
Hodson, Harold Francis
Palmer, Richard Michael John
Sawyer, David Alan
Knowles, Richard Graham
Franz Man, Karl Wildold
Draisdale, Martin James
Smith, steven
Davies, Patricia Ifay Inwa
Clark, Helen Alice Rebecca
Shearer, Barry George
Palmer, Richard Michael John
Sawyer, David Alan
Knowles, Richard Graham
Franz Man, Karl Wildold
Draisdale, Martin James
Smith, steven
Davies, Patricia Ifay Inwa
Clark, Helen Alice Rebecca
Shearer, Barry George
Application Number:
JP16019399A
Publication Date:
January 26, 2005
Filing Date:
June 14, 1995
Export Citation:
Assignee:
THE WELLCOME FOUNDATION LIMITED
International Classes:
A61K31/00; A61K31/195; A61K31/198; A61P5/00; A61P9/00; A61P43/00; C07C257/14; C07C315/02; C07C317/02; C07C317/48; C07C317/50; C07C323/60; C07C327/58; A61K; A61K31/00; C07C; C07C327/00; (IPC1-7): C07C317/50
Foreign References:
| WO1993013055A1 |
Other References:
Biochem. J., (1967), 102, 728-734
Attorney, Agent or Firm:
Kenji Yoshitake
Yukitaka Nakamura
Konno Akio
Noritaka Yokota
Yukitaka Nakamura
Konno Akio
Noritaka Yokota