Title:
INTERMEDIATE FOR MANUFACTURING EPIPODOPHYLLOTOXIN AND RELATED COMPOUNDS, MANUFACTURE AND USE
Document Type and Number:
Japanese Patent JPS61238758
Kind Code:
A
Abstract:
There is provided a novel and efficient stereoselective total synthesis of epipodophyllotoxin and related epipodophyllotoxin compounds of the general formula wherein R1 and R2 each are independently hydrogen or (lower)alkoxy, or R1 and R2, taken together, is methylenedioxy; R4 and R6 each are independently hydrogen or (lower)alkoxy; and R5 is hydrogen or a phenol-protecting group; or an acid addition salt thereof. The present invention also provides novel intermediates and processes for the preparation of said intermediates, which are then converted into known antineoplastic agents.
Inventors:
DORATOREI EMU BUIASU
POORU EMU SUKONEZUNII
POORU EMU SUKONEZUNII
Application Number:
JP8400886A
Publication Date:
October 24, 1986
Filing Date:
April 11, 1986
Export Citation:
Assignee:
BRISTOL MYERS CO
International Classes:
C07C51/00; C07C51/347; C07C51/353; C07C51/367; C07C51/377; C07C62/32; C07C62/34; C07C62/36; C07C62/38; C07C67/00; C07C69/03; C07C69/74; C07C69/757; C07C69/76; C07C69/96; C07C229/46; C07C253/00; C07C255/47; C07C255/52; C07D263/60; C07D261/04; C07D261/20; C07D307/92; C07D317/70; C07D493/04; C07D498/04; C07H3/00; C07H17/04; (IPC1-7): C07C51/353; C07C51/377; C07C62/32; C07C62/34; C07C62/36; C07C62/38; C07C67/00; C07C69/03; C07C69/757; C07C69/76; C07C69/96; C07C99/00; C07C101/30; C07C120/00; C07C121/75; C07D263/60; C07D317/70; C07D493/04; C07D498/04
Attorney, Agent or Firm:
Minoru Nakamura
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