Title:
グリブリドおよび他の薬剤の静脈内投与方法
Document Type and Number:
Japanese Patent JP6506335
Kind Code:
B2
Abstract:
Methods of administering glyburide, or other drug, are disclosed. The novel methods disclosed herein include intravenous methods of administering glyburide, or other drug, over periods of more than an hour, preferably over periods of about 72 hours. The novel methods include administering a bolus of glyburide, or other drug, followed by a first continuous infusion administration of glyburide, or other drug; and optionally a second or further bolus administration of glyburide, or other drug, and/or a second or further continuous infusion administration of glyburide, or other drug. These methods are effective to rapidly achieve a desired level of glyburide, or other drug, and to provide a substantially steady level of glyburide, or other drug, over a desired period of time. The methods disclosed herein may be useful for treating a subject in need of treatment for, e.g., acute stroke (ischemic and hemorrhagic), traumatic brain injury (TBI), spinal cord injury (SCI), myocardial infarction (MI), shock (including hemorrhagic shock), organ ischemia, and ventricular arrhythmias. These methods provide for the rapid achievement and maintenance of therapeutic glyburide, or other drug, plasma levels over an extended period of time, and further avoid excessive levels of drug and so avoid possible drug side-effects.
Inventors:
Sven Martin Jacobson
Application Number:
JP2017051153A
Publication Date:
April 24, 2019
Filing Date:
March 16, 2017
Export Citation:
Assignee:
Biogen Chesapeake LLC
International Classes:
A61J15/00; A61K31/64; A61L33/04; A61P9/00; A61P9/06; A61P9/10; A61P25/00
Domestic Patent References:
| JP2000512266A | ||||
| JP2007538015A |
Foreign References:
| WO2009097443A1 |
Attorney, Agent or Firm:
Takeshi Oshio