PURPOSE: To provide the subject new compound useful as a therapeutic agent for osteoporosis.
CONSTITUTION: The compound of formula I (R is 6-10C alkyl 1,5-disubstituted with lower alkyl), e.g. 7-(1,5-dimethylhexyl)-3-phenyl-4H-1-benzopyranone. The compound of formula I can be produced by using a compound of formula II (R1 is lower alkyl) as a starting raw material, protecting the hydroxyl group with a protection group R2, introducing 4-substituted 5-9C alkyl side chain by Grignard reaction to obtain a compound of formula III, eliminating the protection group and removing the hydroxyl group by dehydration, reducing the double bond of the formed compound by hydrogenation reaction, bonding the obtained phenol derivative to a phenyl acetyl halide by Friedel-Crafts reaction and subjecting the obtained deoxybenzoin compound of formula IV to cyclization reaction.
TORIHARA MASAHIRO
TAMAI HIRONOBU
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