Title:
ISOPRENE DERIVATIVE
Document Type and Number:
Japanese Patent JP3888397
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To obtain a new isoprene derivative, useful as an action enhancer for a carcinostatic agent, e.g. taxol.
SOLUTION: This compound is represented by formal I {(m) is 0-3; (n) is 5-12; A is a cyclo (3-6C) alkyl, etc.; R1 and R2 are each benzyl, etc.; X is a single bond or (CH2)pNH [(p) is 0-3], etc.} and its pharmaceutically permissible salt, e.g. trans-N,N-bis(3,4-dimethoxybenzyl)-N-solanesyl-1,2-diaminocyclohexane. The compound represented by formula I is produced by reacting a compound represented by formula II with a computer represented by formula III (L is a halogen, etc.). The compound represented by formula III in an amount of 0.1-10mol equiv. based on the compound represented by formula II is used at this time and the reaction is carried out in, e.g. an ether solvent at 10-30°C temperature for 5-6hr.
Inventors:
Kohei Inomata
Toshihiro Takahashi
Hitoshi Inoue
Makoto Taniuchi
Hiroyuki Yamazaki
Suzuki Masashi
Tsutomu Takazawa
Kawamura Koji
Norio Oshida
Hiroyuki Ikemoto
Takao Kishie
Toshihiro Takahashi
Hitoshi Inoue
Makoto Taniuchi
Hiroyuki Yamazaki
Suzuki Masashi
Tsutomu Takazawa
Kawamura Koji
Norio Oshida
Hiroyuki Ikemoto
Takao Kishie
Application Number:
JP1821697A
Publication Date:
February 28, 2007
Filing Date:
January 31, 1997
Export Citation:
Assignee:
Nisshin Flour Milling Group Inc.
International Classes:
C07C211/27; C07D295/12; A61K31/135; A61K31/40; A61K31/495; A61K31/535; A61K31/5375; A61P35/00; A61P35/02; A61P35/04; A61P43/00; C07C209/08; C07C211/29; C07C211/40; C07C213/02; C07C215/50; C07C215/54; C07C215/64; C07C217/58; C07C217/62; C07C217/74; C07D207/14; C07D241/04; C07D491/08; (IPC1-7): C07C211/27; A61K31/135; A61K31/40; A61K31/495; A61K31/535; C07C209/08; C07C211/29; C07C211/40; C07C213/02; C07C215/50; C07C215/54; C07C215/64; C07C217/58; C07C217/62; C07C217/74; C07D207/14; C07D241/04; C07D295/12; C07D491/08
Domestic Patent References:
| JP516411B2 |
Attorney, Agent or Firm:
Chika Takagi
Tatsuo Sato
Kosuke Nishimura
Tatsuo Sato
Kosuke Nishimura
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