Title:
LECTIN HAVING TARGET DIRECTIVITY TO CANCER
Document Type and Number:
Japanese Patent JP2013156245
Kind Code:
A
Abstract:
To provide a reagent for detecting prostate cancer, a method for determining prostate cancer and a liposome carrier having a target directivity to prostate cancer.
An effect has been found in which Bauhinia purpurea lectin (BPA) and Maclura pomifera lectin (MPA) bind to sugar chains on the surfaces of cancer cells. By utilizing such an effect, the reagent for detecting prostate cancer and the method for determining prostate cancer have been completed. In addition, by utilizing the effect in which Bauhinia purpurea lectin (BPA) and Maclura pomifera lectin (MPA) bind to the sugar chains on the surfaces of the cancer cells, the surfaces of liposomes are modified by BPA or MPA to have a target directivity to prostate cancer.
Inventors:
SHIMIZU KOSUKE
OKU NAOTO
SHIMIZU MOTOHIRO
OKU NAOTO
SHIMIZU MOTOHIRO
Application Number:
JP2012109464A
Publication Date:
August 15, 2013
Filing Date:
May 11, 2012
Export Citation:
Assignee:
SHIZUOKAKEN KORITSU DAIGAKU HOJIN
SUGIYAMA SANGYO KAGAKU KENK
SUGIYAMA SANGYO KAGAKU KENK
International Classes:
G01N33/574; A61K9/127; A61K31/704; A61K45/00; A61K47/42; A61P35/00; G01N33/53
Foreign References:
| US20060120997A1 | 2006-06-08 |
Other References:
JPN6016007250; Ｙｕｎｇ Ｄ．Ｋｉｍ， Ｄｅｂｏｒａｈ Ｙ．Ｒｏｂｉｎｓｏｎ， Ｊｏｓｅｐｈ Ｔ．Ｔｏｍｉｔａ: 'Ｍｏｎｏｃｌｏｎａｌ Ａｎｔｉｂｏｄｙ ＰＲ９２ ｗｉｔｈ Ｒｅｓｔｒｉｃｔｅｄ Ｓｐｅｃｉｆｉｃｉｔｙ ｆｏｒ Ｔｕｍｏｒ-Ａｓｓｏｃｉａｔｅｄ Ａｎｔｉｇｅｎ ｏｆ Ｐｒｏｓｔａｔｅ ａｎｄ Ｂｒ' Ｃａｎｃｅｒ Ｒｅｓｅａｒｃｈ Ｖｏｌ．４８, 19880815, ｐ．４５４３-４５４８
JPN6016007253; 清水広介， 大橋健人， 奥直人: '前立腺がんを標的としたレクチン修飾リポソームの開発' 杉山産業化学研究所年報 , 20110428, ｐ．５７-６９
JPN6016007257; Ｆｒａｎｚ Ｇａｂｏｒ， Ｕｒｓｕｌａ Ｋｌａｕｓｅｇｇｅｒ， Ｍｉｃｈａｅｌ Ｗｉｒｔｈ: 'ｈｅ Ｉｎｔｅｒａｃｔｉｏｎ ｂｅｔｗｅｅｎ ｗｈｅａｔ ｇｅｒｍ ａｇｇｌｕｔｉｎｉｎ ａｎｄ ｏｔｈｅｒ ｐｌａｎｔ ｌｅｃｔｉｎｓ ｗｉｔｈ ｐｒｏｓｔａｔｅ ｃａｎｃｅｒ ｃｅｌｌｓ Ｄｕ-１' Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｊｏｕｒｎａｌ ｏｆ Ｐｈａｒｍａｃｅｕｔｉｃｓ Ｖｏｌ．２２１, 20010609, ｐ．３５-４７
JPN6016007247; Ｙｕｎｇ Ｄ．Ｋｉｍ， Ｄｅｂｏｒａｈ Ｙ．Ｒｏｂｉｎｓｏｎ， Ｇｅｏｒｇｅ Ｌ．Ｍａｎｄｅｒｉｎｏ， Ｉｌｓｅ Ｉ．Ｅ．Ｔｒｉｂｂｙ， Ｊｏｓｅｐｈ Ｔ．Ｔｏｍｉｔａ: 'Ｍｏｌｅｃｕｌａｒ Ｃｈａｒａｃｔｅｒｉｚａｔｉｏｎ ｏｆ ｔｈｅ Ｅｐｉｔｏｐｅ ｉｎ Ｐｒｏｓｔａｔｅ ａｎｄ Ｂｒｅａｓｔ Ｔｕｍｏｒ-Ａｓｓｏｃｉａｔｅｄ ＰＲ９２ Ａｎｔｉｇｅｎ' Ｃａｎｃｅｒ Ｒｅｓｅａｒｃｈ Ｖｏｌ．４９, 19890501, ｐ．２３７９-２３８２
JPN6016007253; 清水広介， 大橋健人， 奥直人: '前立腺がんを標的としたレクチン修飾リポソームの開発' 杉山産業化学研究所年報 , 20110428, ｐ．５７-６９
JPN6016007257; Ｆｒａｎｚ Ｇａｂｏｒ， Ｕｒｓｕｌａ Ｋｌａｕｓｅｇｇｅｒ， Ｍｉｃｈａｅｌ Ｗｉｒｔｈ: 'ｈｅ Ｉｎｔｅｒａｃｔｉｏｎ ｂｅｔｗｅｅｎ ｗｈｅａｔ ｇｅｒｍ ａｇｇｌｕｔｉｎｉｎ ａｎｄ ｏｔｈｅｒ ｐｌａｎｔ ｌｅｃｔｉｎｓ ｗｉｔｈ ｐｒｏｓｔａｔｅ ｃａｎｃｅｒ ｃｅｌｌｓ Ｄｕ-１' Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｊｏｕｒｎａｌ ｏｆ Ｐｈａｒｍａｃｅｕｔｉｃｓ Ｖｏｌ．２２１, 20010609, ｐ．３５-４７
JPN6016007247; Ｙｕｎｇ Ｄ．Ｋｉｍ， Ｄｅｂｏｒａｈ Ｙ．Ｒｏｂｉｎｓｏｎ， Ｇｅｏｒｇｅ Ｌ．Ｍａｎｄｅｒｉｎｏ， Ｉｌｓｅ Ｉ．Ｅ．Ｔｒｉｂｂｙ， Ｊｏｓｅｐｈ Ｔ．Ｔｏｍｉｔａ: 'Ｍｏｌｅｃｕｌａｒ Ｃｈａｒａｃｔｅｒｉｚａｔｉｏｎ ｏｆ ｔｈｅ Ｅｐｉｔｏｐｅ ｉｎ Ｐｒｏｓｔａｔｅ ａｎｄ Ｂｒｅａｓｔ Ｔｕｍｏｒ-Ａｓｓｏｃｉａｔｅｄ ＰＲ９２ Ａｎｔｉｇｅｎ' Ｃａｎｃｅｒ Ｒｅｓｅａｒｃｈ Ｖｏｌ．４９, 19890501, ｐ．２３７９-２３８２
Attorney, Agent or Firm:
Masaki Hirota
Seiji Ozawa
Yusaku Tokai
Large High Toshiko
High Kazuya Tsu
Makoto Horiuchi
Seiji Ozawa
Yusaku Tokai
Large High Toshiko
High Kazuya Tsu
Makoto Horiuchi