Title:
LIVER PROPAGATION PROMOTING SUBSTANCE AND PRODUCTION
Document Type and Number:
Japanese Patent JPS54140708
Kind Code:
A
Abstract:
A factor which causes an increase in the number of liver cells through increased cell division activity, obtained by homogenizing the remaining livers of partially hepatectomized animals, subjecting the homogenate to acidification to pH=5.5 and then heat treatment at 95 DEG C., and centrifuging said homogenate. After such treatment, the factor is contained in the supernatant. The factor is a neuraminic-acid-free protein with a molecular weight of approximately 30,000 to 50,000 D. An extract containing the factor also can be obtained from the blood plasma of hepatectomized animals, when the plasma in addition to the described steps further is treated with neuraminidase. Similarly, an extract containing the factor can be obtained from the livers or the plasma of non-hepatectomized fetal or very young animals.
Inventors:
GEERUHANTO RUUENSUTOROTSUTOOBA
MIHAERU GORUTOBERUKU
JIIKU FURIIDO JIRUTSU
UORUFUGANGU SHIYUTORETSUKAA
MIHAERU GORUTOBERUKU
JIIKU FURIIDO JIRUTSU
UORUFUGANGU SHIYUTORETSUKAA
Application Number:
JP4242179A
Publication Date:
November 01, 1979
Filing Date:
April 07, 1979
Export Citation:
Assignee:
MAX PLANCK GESELLSCHAFT
International Classes:
A61K35/16; A61K35/407; A61K38/16; A61P1/16; A61P43/00; (IPC1-7): A61K35/16; A61K35/40