Title:
発光ナノ粒子、それを用いた細胞の検出方法、動物の治療方法、医療装置、細胞の可視化方法、及び細胞の損傷軽減方法
Document Type and Number:
Japanese Patent JP6820154
Kind Code:
B2
Abstract:
Provided are light-emitting nanoparticles that exhibit light emission stability and light resistance, and are less biologically toxic. The light-emitting nanoparticles contain a matrix material and a light-emitting substance included in the matrix material, wherein the matrix material contains a cationic element that is at least one member selected from the group consisting of Ti, Si, Ca, Al and Zr, and an anionic element that is at least one member selected from the group consisting of O and P; and the concentration of the light-emitting substance in the matrix material is set to a level that results in an average distance of 1.2 nm or more between pieces of the light-emitting substance.
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Inventors:
Masahiko Inui
Tadani
Motohiro Tagaya
Satoshi Motozuka
Tadani
Motohiro Tagaya
Satoshi Motozuka
Application Number:
JP2016064240A
Publication Date:
January 27, 2021
Filing Date:
March 28, 2016
Export Citation:
Assignee:
OHARA CORPORATION
Nagaoka University of Technology
National Institute of Technology
Nagaoka University of Technology
National Institute of Technology
International Classes:
C09K11/59; A61K9/51; A61K41/00; A61K47/02; A61K47/52; A61P35/00; B82Y5/00; B82Y20/00; B82Y30/00; C09K11/06; C09K11/67; C09K11/71; G01N21/64; G01N33/48
Other References:
TAGAYA, M. et al.,Synthesis of Luminescent Nanoporous Silica Spheres Functionalized with Folic Acid for Targeting to Cancer Cells,Inorganic Chemistry,2014, Vol. 53,p. 6817-6827
TAGAYA, M. et al.,In Vitro Targeting of Cancer Cells with Luminescent Nanoporous Silica Spheres,Transactions on GIGAKU,2012, Vol. 1, No. 01014,p. 1-8
TAGAYA, M. et al.,Synthesis and Luminescence Properties of Eu(III)-doped Nanoporous Silica Spheres,Journal of Colloid and Interface Science,2011, Vol. 363, No. 2,p. 456-464
TAGAYA, M. et al.,Efficient Synthesis of Eu(III)-Containing Nanoporous Silicas,Materials Letters,2011, Vol. 65, No. 14,p. 2287-2290
多賀谷基博,高次構造制御された無機/有機ナノ複合体の創製と光機能化,DV-Xα研究協会会報,2014, Vol.26, No.1-2,p. 22-26
SHIBA, K. et al.,Synthesis of Cytocompatible Luminescent Titania/Fluorescein Hybrid Nanoparticles,ACS Applied Materials & Interfaces,2014, Vol.6, No. 9,p.6825-6834
SHIBA, K. et al.,Preparation of Luminescent Titania/Dye Hybrid Nanoparticles and Their Dissolution Properties for Controlling Cellular Environments,RSC Advances,2015, Vol. 5, No. 5,p. 104343-104353
竹田龍平 ほか,Eu添加アパタイト粒子の合成と発光特性,DV-Xα研究協会会報,2012, Vol. 24, No. 1-2,p. 243-246
TAGAYA, M. et al.,In Vitro Targeting of Cancer Cells with Luminescent Nanoporous Silica Spheres,Transactions on GIGAKU,2012, Vol. 1, No. 01014,p. 1-8
TAGAYA, M. et al.,Synthesis and Luminescence Properties of Eu(III)-doped Nanoporous Silica Spheres,Journal of Colloid and Interface Science,2011, Vol. 363, No. 2,p. 456-464
TAGAYA, M. et al.,Efficient Synthesis of Eu(III)-Containing Nanoporous Silicas,Materials Letters,2011, Vol. 65, No. 14,p. 2287-2290
多賀谷基博,高次構造制御された無機/有機ナノ複合体の創製と光機能化,DV-Xα研究協会会報,2014, Vol.26, No.1-2,p. 22-26
SHIBA, K. et al.,Synthesis of Cytocompatible Luminescent Titania/Fluorescein Hybrid Nanoparticles,ACS Applied Materials & Interfaces,2014, Vol.6, No. 9,p.6825-6834
SHIBA, K. et al.,Preparation of Luminescent Titania/Dye Hybrid Nanoparticles and Their Dissolution Properties for Controlling Cellular Environments,RSC Advances,2015, Vol. 5, No. 5,p. 104343-104353
竹田龍平 ほか,Eu添加アパタイト粒子の合成と発光特性,DV-Xα研究協会会報,2012, Vol. 24, No. 1-2,p. 243-246
Attorney, Agent or Firm:
Masayuki Masabayashi
Hayashi Ichiyoshi
Hayashi Ichiyoshi