Title:
リジン特異的なデメチラーゼ−１の阻害剤
Document Type and Number:
Japanese Patent JP6983273
Kind Code:
B2
Abstract:
The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted heterocyclic derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition of lysine specific demethylase-1. Furthermore, the subject compounds and compositions are useful for the treatment of cancer, such as prostate cancer, breast cancer, bladder cancer, lung cancer and/or melanoma and the like.
Inventors:
Chen, Young, Kay.
Kanouni, Tofique
Stafford, Jeffrey, Alan
Vir, james, marvin
Kanouni, Tofique
Stafford, Jeffrey, Alan
Vir, james, marvin
Application Number:
JP2020072573A
Publication Date:
December 17, 2021
Filing Date:
April 14, 2020
Export Citation:
Assignee:
Celgene Quantisell Research, Inc.
International Classes:
C07D401/14; A61K31/4439; A61K31/4545; A61K31/501; A61K31/506; A61K31/53; A61P35/00; A61P43/00; C07D403/14; C07D471/04
Domestic Patent References:
| JP2008536950A | ||||
| JP2009525311A | ||||
| JP6430512B2 | ||||
| JP2011529468A | ||||
| JP2005500294A | ||||
| JP2007532676A |
Foreign References:
| WO2012013727A1 | ||||
| WO2005058876A1 |
Other References:
Hitchin, James R.; Blagg, Julian; Burke, Rosemary; Burns, Samantha; Cockerill, Mark J.; Fairweather,,Development and evaluation of selective, reversible LSD1 inhibitors derived from fragments,MedChemComm,2013年,4(11),1513-1522
Biochimica et Biophysica Acta,2014年05月21日,1839(12),1416-1432
C.G.WERMUTH編,『最新 創薬化学 上巻』,株式会社テクノミック,1998年08月15日,235-271頁,13章 等価置換に基づく分子の変換
野崎正勝 等,創薬化学,第1版,株式会社化学同人,1995年,p.98-99
Wustrow, David J.; Maynard, George D.; Yuan, Jun; Zhao, He; Mao, Jianmin; Guo, Qin; Kershaw, Mark; H,Aminopyrazine CB1 receptor inverse agonists,Bioorganic & Medicinal Chemistry Letters,2008年,18(11),3376-3381
Constable, Edwin C.; Housecroft, Catherine E.; Neuburger, Markkus; Reymann, Sebastien; Schaffner, Si,4-Substituted and 4,5-disubstituted 3,6-di(2-pyridyl)pyridazines: ligands for supramolecular assembl,European Journal of Organic Chemistry,2008年,(9),1597-1607
Doebelin, Christelle; Wagner, Patrick; Bihel, Frederic; Humbert, Nicolas; Kenfack, Cyril Assongo; Me,Fully regiocontrolled polyarylation of pyridine,Journal of Organic Chemistry,2014年,79(3),908-918
Mould, Daniel P.; McGonagle, Alison E.; Wiseman, Daniel H.; Williams, Emma L.; Jordan, Allan M.,Reversible Inhibitors of LSD1 as Therapeutic Agents in Acute Myeloid Leukemia: Clinical Significance,Medicinal Research Reviews,2015年,35(3),586-618
Biochimica et Biophysica Acta,2014年05月21日,1839(12),1416-1432
C.G.WERMUTH編,『最新 創薬化学 上巻』,株式会社テクノミック,1998年08月15日,235-271頁,13章 等価置換に基づく分子の変換
野崎正勝 等,創薬化学,第1版,株式会社化学同人,1995年,p.98-99
Wustrow, David J.; Maynard, George D.; Yuan, Jun; Zhao, He; Mao, Jianmin; Guo, Qin; Kershaw, Mark; H,Aminopyrazine CB1 receptor inverse agonists,Bioorganic & Medicinal Chemistry Letters,2008年,18(11),3376-3381
Constable, Edwin C.; Housecroft, Catherine E.; Neuburger, Markkus; Reymann, Sebastien; Schaffner, Si,4-Substituted and 4,5-disubstituted 3,6-di(2-pyridyl)pyridazines: ligands for supramolecular assembl,European Journal of Organic Chemistry,2008年,(9),1597-1607
Doebelin, Christelle; Wagner, Patrick; Bihel, Frederic; Humbert, Nicolas; Kenfack, Cyril Assongo; Me,Fully regiocontrolled polyarylation of pyridine,Journal of Organic Chemistry,2014年,79(3),908-918
Mould, Daniel P.; McGonagle, Alison E.; Wiseman, Daniel H.; Williams, Emma L.; Jordan, Allan M.,Reversible Inhibitors of LSD1 as Therapeutic Agents in Acute Myeloid Leukemia: Clinical Significance,Medicinal Research Reviews,2015年,35(3),586-618
Attorney, Agent or Firm:
Akio Miyazaki
Masaaki Ogata
Masaaki Ogata