MALONYL-CoA DECARBOXYLASE INHIBITOR USEFUL AS METABOLIC MODULATOR

Title:

MALONYL-CoA DECARBOXYLASE INHIBITOR USEFUL AS METABOLIC MODULATOR

Document Type and Number:

Japanese Patent JP2010065054

Kind Code:

A

Abstract:

To provide new compounds, their prodrugs, and their pharmaceutically acceptable salts as well as pharmaceutical compositions containing such compounds useful in treating specific metabolic diseases and diseases modulated by the inhibition of the enzyme malonyl-coenzyme A decarboxylase (malonyl-CoA decarboxylase, MCD).

The new compound expressed by general formula (I) and their prodrug are disclosed. In particular, the compound, composition and method for the prophylaxis, control and treatment of cardiovascular diseases, diabetes, acidosis, cancers, and obesity through the inhibition of malonyl-coenzyme A decarboxylase are disclosed.

More Like This:

WO/2023/011312	MULTI-SUBSTITUTED THIAZOLE DERIVATIVE AND APPLICATION THEREOF IN DISEASE TREATMENT
JP2001524074	INDUSTRIAL APPLICABILITY Pyrrolidine and thiazole derivatives having metal-β-lactamase inhibitory properties.
WO/2023/196278	ITK INHIBITORS FOR INCREASING TH1 CELL ACTIVITY

Inventors:

ARRHENIUS THOMAS
CHEN MI
CHENG JIE FEI
HUANG YUJIN
NADZAN ALEX
RICHARD PENULIAR
WALLACE DAVID
ZHANG LIN
LOPASCHUK GARY D
DYCK JASON R

Application Number:

JP2009261692A

Publication Date:

March 25, 2010

Filing Date:

November 17, 2009

Export Citation:

Click for automatic bibliography generation Help

Assignee:

CHUGAI PHARMACEUTICAL CO LTD

International Classes:

A61K31/426; A61K31/045; A61K31/095; A61K31/133; A61K31/137; A61K31/16; A61K31/165; A61K31/341; A61K31/41; A61K31/415; A61K31/4164; A61K31/42; A61K31/422; A61K31/427; A61K31/433; A61K31/44; A61K31/4439; A61K31/444; A61K31/454; A61K31/505; A61K31/5375; A61K31/55; A61K31/664; A61P3/00; A61P3/04; A61P3/10; A61P3/12; A61P9/00; A61P9/04; A61P9/10; A61P35/00; A61P43/00; C07C33/48; C07C215/24; C07C233/22; C07C307/10; C07C323/14; C07D233/54; C07D239/42; C07D261/04; C07D261/08; C07D277/20; C07D277/46; C07D277/48; C07D277/52; C07D285/135; C07D307/46; C07D401/12; C07D413/04; C07D413/06; C07D413/12; C07D417/12; C07D417/14; C07D487/08; C07D498/08; C07F9/24; C07F9/6539; C07D285/12

Foreign References:

WO2001003705A1	2001-01-18
WO2000054759A2	2000-09-21
WO2001003705A1	2001-01-18
WO2000054759A2	2000-09-21

Attorney, Agent or Firm:

Hatsushi Shimizu
Toshi Gobe
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Ryuichi Inoue

Previous Patent: METHOD OF PREVENTING PRODUCTION OF AIRWAY MUCUS BY ADMINISTRATION OF EGF-R ANTAGONIST

Next Patent: CONTACT LENS LOADING OR PRESERVING AGENT AND AGAR-CONTAINING OPHTHALMIC SOLUTION