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Title:
METHOD OF PREVENTING PRODUCTION OF AIRWAY MUCUS BY ADMINISTRATION OF EGF-R ANTAGONIST
Document Type and Number:
Japanese Patent JP2010065053
Kind Code:
A
Abstract:

To provide a method of preventing hypersecretion of mucus in an airway and a pharmaceutical formulation for lowering excess formation of lung cells in the airway.

This method of lowering excess formation of lung cells in individual airways includes administration of an effective amount for the treatment of an epidemic growth factor receptor (EGF-R) antagonist to a patient affected by hypersecretion of mucus in the airway by excess formation of lung cells in the airway, and this pharmaceutical formation for lowering the excess formation of lung cells in the airway contains the antagonist and a pharmaceutically permissible carrier. As the antagonist, a kinase inhibitor selective to EGF-R, a monoclonal antibody specifically bonding to the epidemic growth factor, antioxidants, etc., are preferable.


Inventors:
NADEL JAY A
TAKEYAMA TADASHI
Application Number:
JP2009261019A
Publication Date:
March 25, 2010
Filing Date:
November 16, 2009
Export Citation:
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Assignee:
UNIV CALIFORNIA
International Classes:
A61K9/08; A61K45/00; A01K67/027; A61K9/12; A61K9/127; A61K9/72; A61K31/00; A61K38/17; A61K39/395; A61P11/00; A61P11/02; A61P11/06; A61P11/12; A61P27/16; A61P35/00; A61P39/06; A61P43/00; G01N33/50
Attorney, Agent or Firm:
Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Masato Ozeki
Kazuya Kawamoto