ＭＩＲＡＣタンパク質

Title:

ＭＩＲＡＣタンパク質

Document Type and Number:

Japanese Patent JP6647330

Kind Code:

B2

Abstract:

A method of generating conditionally active biologic antibodies from parent antibodies, in particular therapeutic antibodies, which are more active at an aberrant physiological condition than at a normal physiological condition and which may reversibly or irreversibly inactivated at the wild type normal physiological condition. For example, evolved antibodies are may be less active or inactive at normal body temperature or pH, than at other aberrant body temperatures or at an aberrant pH.

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Inventors:

Short, Jay, M.
Chang, Huway, Wen
Frey, Gerhard

Application Number:

JP2018022055A

Publication Date:

February 14, 2020

Filing Date:

February 09, 2018

Export Citation:

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Assignee:

Bio Atla, LLC

International Classes:

C12P21/02; A61K9/06; A61K9/08; A61K9/107; A61K38/095; A61K39/395; A61P35/00; C07K16/18; C12N15/10; G01N33/53

Domestic Patent References:

JP2008534676A
JP2008510466A

Foreign References:

US20050260711
WO2009125825A1
WO1995014710A1

Attorney, Agent or Firm:

Taro Yaguchi

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