MLK4遺伝子、新規の癌診断および予後マーカー

Title:

MLK4遺伝子、新規の癌診断および予後マーカー

Document Type and Number:

Japanese Patent JP2013528394

Kind Code:

A

Abstract:

An in vitro diagnostic method for determining invasive potential of cancer comprising measuring MLK4 gene expression in a cancer cell sample, wherein MLK4 gene overexpression is indicative of an invasive cancer, preferably a colorectal, bladder, breast, gastric, melanoma, lung, ovary or GMB cancer.

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Inventors:

Alberto Valdelli
Miriam Martini

Application Number:

JP2013514792A

Publication Date:

July 11, 2013

Filing Date:

June 15, 2010

Export Citation:

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Assignee:

Alberto Valdelli
Miriam Martini

International Classes:

C12Q1/68; C12N15/09

Foreign References:

WO2005095631A2	2005-10-13
WO2004082458A2	2004-09-30

Other References:

JPN6014042805; Ｄｉｇｅｓｔｉｖｅ　ａｎｄ　Ｌｉｖｅｒ　ＤｉｓｅａｓｅＶｏｌ．３８, 2006, ｐ．２８３-２８６
JPN6014042799; ＭＡＲＴＩＮＩ　Ｍ．　ｅｔ　ａｌ: 'ＭＬＫ４，　ａ　ｎｏｖｅｌ　ｏｎｃｏｇｅｎｉｃ　ｋｉｎａｓｅ　ｉｎ　ｔｈｅ　ＲＡＳ　ｐａｔｈｗａｙ' ＳＩＢＢＭ　Ｓｅｍｉｎａｒ"Ｆｒｏｎｔｉｅｒｓ　ｉｎ　Ｍｏｌｅｃｕｌａｒ　Ｂｉｏｌｏｇｙ"Ｐａｄｕａ　３-５　Ｊｕｎｅ　２０１０ , 20100605, ＳＩＢＢＭ　Ｓｅｍｉｎａｒ
JPN6014042801; ＢＡＲＤＥＬＬＩ　Ａｌｂｅｒｔｏ: 'Ａｌｔｅｒａｚｉｏｎｉ　ｇｅｎｅｔｉｃｈｅ　ｅ　ａｎａｌｉｓｉ　ｆｕｎｚｉｏｎａｌｅ　ｄｅｌｌａ　ｐｒｏｔｅｉｎａ　ｃｈｉｎａｓｉ　ＭＬＫ４　ｎｅｉ　ｔｕｍｏｒｉ　ｕｍａｎｉ' ＯＳＩＲＩＳ　-　Ｃｅｎｔｒｏ　ｄｉ　Ｄｏｃｕｍｅｎｔａｚｉｏｎｅ　ｅ　Ｃｏｎｄｉｖｉｓｉｏｎｅ　ｄｅｌｌｅ　Ｃｏｎｏｓｃｅｎｚｅ , 20091012, ＯＳＩＲＩＳ
JPN6014042803; ＳｃｉｅｎｃｅＶｏｌ．３００, 2003, ｐ．９４９

Attorney, Agent or Firm:

Shinjiro Ono
Yasushi Kobayashi
Hiroyuki Tomita
Osamu Hoshino
Akiko Nakahama

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