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Title:
MACROPHAGE INFLAMMATION PROTEIN VARIETY
Document Type and Number:
Japanese Patent JP3722819
Kind Code:
B2
Abstract:

PROBLEM TO BE SOLVED: To obtain a SCI/MIPI-α variety which, though substantially retaining the activity of protein in the native state, does not form large-sized agglutinates similar to that formed by the protein in the native state.
SOLUTION: The protein has a stem cell inhibition activity, has amino acid sequences containing sequences from amino acid 28 to amino acid 93 in specific amino acid sequences accompanied by amino acid substitution at one or more amino acid positions selected from the group consisting of 80(Glu), 84(Lys), 88(Asp), and 90(Glu), and does not significantly agglutinate.


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Inventors:
Gerrard Graham
Ian Punnell
Application Number:
JP2004030857A
Publication Date:
November 30, 2005
Filing Date:
February 06, 2004
Export Citation:
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Assignee:
CANCER RESEARCH TECHNOLOGY LIMITED
International Classes:
C12N15/09; A61K38/00; A61K38/22; A61P17/06; A61P35/00; A61P35/02; A61P39/00; A61P43/00; C07K14/47; C07K14/52; C12N1/21; C12N15/19; C12P21/02; (IPC1-7): C07K14/47; A61K38/00; A61P17/06; A61P35/00; A61P35/02; A61P43/00; C12P21/02
Foreign References:
WO1991004274A1
Other References:
Proc. Natl. Acad. Sci. USA, 1993 Mar., Vol.90, No.6, pages 2232-6
Attorney, Agent or Firm:
Aoyama Aoi
Mitsuo Tanaka



 
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