代謝調節剤として有用なマロニル-CoA脱炭酸酵素阻害剤

Japanese Patent JP5113823

B2

The present invention relates to novel compounds (I), their prodrugs, and the pharmaceutically acceptable salts as well as pharmaceutical compositions containing such compounds useful in treating certain metabolic diseases and diseases modulated by the inhibition of the enzyme malonyl-coenzyme A decarboxylase (malonyl-CoA decarboxylase, MCD). In particular, the invention relates to compounds and compositions and the methods for the prophylaxis, management and treatment of cardiovascular diseases, diabetes, acidosis, cancers, and obesity through the inhibition of malonyl-coenzyme A decarboxylase.

Argenius Thomas
Chen Me
Cheng Chi Fay
Fan uchin
Nathan alex
Penn Richard
Wallace David
Tsang Lin
Ropa Schuk Gary Dee.
Dick Jason Earl.

JP2009261692A

January 09, 2013

November 17, 2009

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Chugai Pharmaceutical Co., Ltd.

C07D277/20; A61K31/045; A61K31/095; A61K31/133; A61K31/137; A61K31/16; A61K31/165; A61K31/341; A61K31/41; A61K31/415; A61K31/4164; A61K31/42; A61K31/422; A61K31/426; A61K31/427; A61K31/433; A61K31/44; A61K31/4439; A61K31/444; A61K31/454; A61K31/505; A61K31/5375; A61K31/55; A61K31/664; A61K33/42; A61P3/00; A61P3/04; A61P3/10; A61P3/12; A61P9/00; A61P9/04; A61P9/10; A61P35/00; A61P43/00; C07C33/48; C07C215/24; C07C233/22; C07C307/10; C07C323/14; C07D233/54; C07D239/42; C07D261/04; C07D261/08; C07D277/46; C07D277/48; C07D277/52; C07D285/12; C07D285/135; C07D307/46; C07D401/12; C07D413/04; C07D413/06; C07D413/12; C07D417/12; C07D417/14; C07D487/08; C07D498/08; C07F9/24; C07F9/6539

WO2001003705A1
WO2000054759A1

Hatsushi Shimizu
Toshi Gobe
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Ryuichi Inoue

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