Title:
MANUFACTURE OF 7-(D(-)-ALPHA-AMINO-P- HYDROXYPHENYLACETAMIDE)DESACETOXYCEPHALOSPORANIC ACID
Document Type and Number:
Japanese Patent JPS56135490
Kind Code:
A
Abstract:
There is described a process for the preparation of 7-(D(-)-alpha-amino-p-hydroxyphenylacetamido)desacetoxycephalosporanic acid in which a D(-)-p-hydroxy-N-(1-alcoxycarbonyl-2-propenyl)-alpha-aminophenylacetic acid salt is reacted with trimethylsilyl-2-oxazolidinone. The resulting reaction product is reacted in turn with an acyl chloride or an alkyl chloroformate to give a mixed anhydride which is reacted with a solution of 7-aminodesacetoxycephalosporanic acid prepared by silylation, in an anhydrous organic solvent, with trimethylsilyl-2-oxazolidinone.
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Inventors:
ANTONIO RUISU PAROMO KORU
JIYOSE JIAGO MESEGERU
ASANSHION ESUTEEBU BIANSHINI
ESUTEBE SAN PITARUHI
JIYOSE JIAGO MESEGERU
ASANSHION ESUTEEBU BIANSHINI
ESUTEBE SAN PITARUHI
Application Number:
JP2230581A
Publication Date:
October 22, 1981
Filing Date:
February 19, 1981
Export Citation:
Assignee:
GEMA SA
International Classes:
A61K31/545; C07D501/04; C07D501/06; C07D501/22; C07D; (IPC1-7): C07D501/06