Title:
MANUFACTURE OF COUMARINE DERIVATIVE
Document Type and Number:
Japanese Patent JPS5569575
Kind Code:
A
Abstract:
A selective process for the preparation of substantially pure 8- halo-3-( beta -diethylaminoethyl)-4- methyl-7-ethoxycarbonylmethoxy coumarin comprises a) reacting a 2- haloresorcinol with alpha -acetyl- gamma - butyrolactone in the presence of KBr and acetic acid, b) reacting the resulting 3-( beta -bromoethyl)-4-methyl- 7-hydroxy-8-halocoumarin with ethyl chloroacetate and reacting the product with diethylamine in the presence of anhydrous K2CO3 to obtain the desired final product. Steps a) and b) may be reversed. Acid addition salts of the final product are disclosed.
Inventors:
FURANSESUKO DERA BUATSURE
Application Number:
JP14376579A
Publication Date:
May 26, 1980
Filing Date:
November 05, 1979
Export Citation:
Assignee:
FIDIA SPA
International Classes:
C07D311/16; (IPC1-7): C07D311/16