Title:
MANUFACTURE OF HETEROCYCLIC COMPOUND
Document Type and Number:
Japanese Patent JPS6277381
Kind Code:
A
Abstract:
The invention relates to a process for the preparation of compounds of general formula (I)whereinR' represents a hydrogen atom or a C1-10 alkyl, C3-7 cycloalkyl, C3-7 cycloalkyl-(C1-4)alkyl, C3-6 alkenyl, C3-10 alkynyl, phenyl or phenyl-(C1-3)alkyl group, and one of the groups represented by R2, R3 and R4 is a hydrogen atom or a C,.6 alkyl, C3-7 cycloalkyl, C2-6 alkenyl or phenyl-IC1-3)alkyl group and each of the other two groups, which may be the same or different, represents a hydrogen atom or a C1-6 alkyl group; or a salt or protected derivative thereof by cyclisation of a compound of general formula (ll)wherein X represents a hydrogen atom or a halogen atom and R', R2, R3, and R4 are as defined above, or a salt or a protected derivative thereof.The compounds of formula (I) are potent and selective antagonists at "neuronal" 5-hydroxytryptamine receptors.
Inventors:
GODFREY NEIL (GB)
COATS IAN H (GB)
BELL JAMES A (GB)
HUMBER DAVID C (GB)
EWAN GEORGE B (GB)
COATS IAN H (GB)
BELL JAMES A (GB)
HUMBER DAVID C (GB)
EWAN GEORGE B (GB)
Application Number:
JP17468486A
Publication Date:
April 09, 1987
Filing Date:
July 24, 1986
Export Citation:
Assignee:
GLAXO GROUP LTD
International Classes:
C07C221/00; C07C225/14; C07D233/60; C07D403/06; C07D233/61; C07D521/00; A61K31/415; (IPC1-7): C07D209/00; C07D233/00; C07D233/61; C07D403/06
Attorney, Agent or Firm:
Kazuo Sato