MANUFACTURE OF PIROXICAM AND SYNTHESIS INTERMEDIATE

Title:

MANUFACTURE OF PIROXICAM AND SYNTHESIS INTERMEDIATE

Document Type and Number:

Japanese Patent JPS5872574

Kind Code:

A

Abstract:

Processes for the preparation of the antiinflammatory agent piroxicam and intermediates leading thereto, the first of which comprises reacting N-methylsaccharin with (N-2-pyridyl)haloacetamides and alkyl haloacetates in the presence of a metal hydride to give, respectively, piroxicam and alkyl 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxides, intermediates which can be converted into piroxicam; and the second of which comprises reacting a novel alkyl 2-(2-methyl-3-hydroxy2,3-dihydro-1,2-benzisosulfonazol-3-yl)-2-haloace tate with a metal hydride to give alkyl 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxides, intermediates leading to piroxicam.

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Inventors:

WEEKS PAUL DOUGLAS (US)

Application Number:

JP17524982A

Publication Date:

April 30, 1983

Filing Date:

October 05, 1982

Export Citation:

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Assignee:

PFIZER

International Classes:

B01J23/04; C07B61/00; C07D213/75; C07D275/06; C07D279/02; C07D417/12; (IPC1-7): C07D275/06; C07D279/02; C07D417/12

Attorney, Agent or Firm:

Kyozo Yuasa

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