Title:
MANUFACTURING METHOD OF SOLUTION OF β-1,3-GLUCAN, β-1,3-GLUCAN COMPOSITE OBTAINED THEREBY, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME
Document Type and Number:
Japanese Patent JP2019006934
Kind Code:
A
Abstract:
To provide a manufacturing method of a solution of β-1,3-glucan capable of dissolving β-1,3-glucan, which is insoluble in neutral water at a triple helix state, in the neutral water without deteriorating physiological activity, biocompatibility or the like, β-1,3-glucan complex obtained by the method, and a pharmaceutical composition containing the same.SOLUTION: There is provided a manufacturing method of a solution of β-1,3-glucan in which 3 β-1,3-glucans form a complex having triplet helix structure in natural water, including: Process (1): a process for dissolving β-1,3-glucan, which has poor solubility in neutral water, in an alkali solution; Process (2): a process for mixing the alkali solution of β-1,3-glucan, and a buffer containing oligonucleotide or a derivative thereof of 1 wt.% to 80 wt.% of the β-1,3-glucan; and Process (3): a process for neutralizing the alkali solution containing the β-1,3-glucan, in order of (1), (2) and (3) or (1), (3) and (2).SELECTED DRAWING: None
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Inventors:
SAKURAI KAZURO
MOCHIZUKI SHINICHI
NIWA TAKAKO
MOCHIZUKI SHINICHI
NIWA TAKAKO
Application Number:
JP2017125509A
Publication Date:
January 17, 2019
Filing Date:
June 27, 2017
Export Citation:
Assignee:
UNIV OF KITAKYUSHU
DAIICHI SANKYO CO LTD
DAIICHI SANKYO CO LTD
International Classes:
C08B37/00; A61K31/7088; A61K31/716; A61K47/26; A61K47/54; A61P37/04; A61P43/00
Attorney, Agent or Firm:
Kazuaki Nakajima