MATERIALS AND METHODS OF ENHANCING HEMATOPOIETIC STEM CELL ENGRAFTMENT PROCEDURES

Japanese Patent JP2023052244

A

To provide methods of enhancing hematopoietic stem cell (HSPC) and hematopoietic stem cell progenitor cell (HSPC) engraftment procedures.SOLUTION: Treatment in vivo of a HSPC donor with compounds that reduce PGE2 biosynthesis or PGE2 receptor antagonists alone or in combination with other hematopoietic mobilization agents such as AMD3100 and G-CSF, increases the circulation of available HSPCs. Compounds that reduce the cellular synthesis of PGE2 include non-steroidal anti-inflammatory compounds such as indomethacin. Treatment ex vivo of HSPC with an effective amount of PGE2 or at least one of its derivatives such as 16,16-dimethyl prostaglandin E2 (dmPGE2), promotes HSPC engraftment. Similar methods may also be used to increase viral-mediated gene transduction efficacy into HSPC.SELECTED DRAWING: None

WO/1995/021527	STEM CELL ENGRAFTMENT
WO/2012/032525	AN IMMUNOSUPPRESSIVE DRUG COMBINATION FOR A STABLE AND LONG TERM ENGRAFTMENT
JP6810706	Mesenchymal stem cells for alleviation or amelioration of bullous epidermal exfoliation-hydrogel-biodegradable or mesenchymal stem cells-hydrogel-non-degradable support composition

Perlas, Lewis, M.
Hogat, Jonathan
Shin, Prativa

JP2023001015A

April 11, 2023

January 06, 2023

Click for automatic bibliography generation  

INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION

A61K35/28; A61K31/192; A61K31/196; A61K31/365; A61K31/4035; A61K31/405; A61K31/407; A61K31/4196; A61K31/42; A61K31/444; A61K31/5415; A61K31/5575; A61K31/616; A61K31/63; A61K35/50; A61K35/51; A61K35/76; A61K38/16; A61K45/00; A61K45/06; A61K48/00; A61P43/00; A61K35/12

Hiroshi Kobayashi
Norio Omori
Emiko Nishizawa

Previous Patent: Interaction with 3D virtual objects using pose and multiple DOF controllers

Next Patent: display panel