Title:
マトリックスメタロプロテイナーゼ阻害剤
Document Type and Number:
Japanese Patent JP2006526590
Kind Code:
A
Abstract:
Compounds of formula (I): wherein: Q represents an optionally substituted 5- or 6-membered aryl or heteroaryl ring; X represents O, S, NR5 or CR6 R7; Y represents CHOH, CHSH, NOR8, CNR8 or CNOR8; Z represents a bond, CR10R11, O, S, SO, SO2, NR10, OCR10R11, CR10R11 O or Z, R4 and Q together form an optionally substituted fused tricyclic group; R1, R1', R3 and R3' each independently represents H, C1-6 alkyl or C1-4 alkylaryl; R2 represents CO2R8, CONR5OR9 or NR5COR9; R4 represents optionally substituted 5- or 6-membered aryl or heteroaryl; R5 represents H or C1-3 alkyl; R6 and R7 each independently represents H, C1-3 alkyl or halo; R8 represents H or C1-2 alkyl; R9 represents H or C1-3 alkyl; R10 and R11 each independently represents H, C1-6 alkyl or C1-4 alkylaryl; and physiologically functional derivatives thereof, processes for their preparation, pharmaceutical formulations containing them and their use as inhibitors of matrix metalloproteinase enzymes (MMPs) are described.
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Inventors:
Gaines, Simon
Holmes, Ian, Peter
Watson, Stephen, Paul
Holmes, Ian, Peter
Watson, Stephen, Paul
Application Number:
JP2006508257A
Publication Date:
November 24, 2006
Filing Date:
June 01, 2004
Export Citation:
Assignee:
GLAXO GROUP LIMITED
International Classes:
C07C59/48; A61K31/192; A61K31/275; A61K31/343; A61K31/426; A61P9/00; A61P11/00; A61P19/02; A61P29/00; A61P37/02; A61P43/00; C07C17/16; C07C51/353; C07C59/52; C07C59/54; C07C59/56; C07C59/68; C07C59/90; C07C205/56; C07C233/54; C07C255/57; C07C323/62; C07D277/04; C07D307/91; C07B61/00
Attorney, Agent or Firm:
Yusuke Hiraki
Ishii Teiji
Satoshi Fujita
Ishii Teiji
Satoshi Fujita