MEDIA USED FOR DIRECT TRANSDIFFERENTIATION OF MACROPHAGES INTO NEURONS AND USES THEREOF

Title:

MEDIA USED FOR DIRECT TRANSDIFFERENTIATION OF MACROPHAGES INTO NEURONS AND USES THEREOF

Document Type and Number:

Japanese Patent JP2022127433

Kind Code:

A

Abstract:

To provide media for direct transdifferentiation of macrophages into neurons, to provide methods for producing neurons using the media, and to provide methods for direct transdifferentiation of macrophages into neurons.SOLUTION: A medium used for direct transdifferentiation of macrophages into neurons comprises a glycogen synthase kinase 3 inhibitor, an adenylate cyclase activator, a Rho Kinase Inhibitor, a neural differentiation inducer, and a PU.1 inhibitor. A method for producing neurons and a method for direct transdifferentiation of macrophages into neurons comprise a transdifferentiation step of culturing macrophages with the medium comprising a glycogen synthase kinase 3 inhibitor, an adenylate cyclase activator, a Rho Kinase Inhibitor, a neural differentiation inducer, and a PU.1 inhibitor to directly transdifferentiate them into neurons.SELECTED DRAWING: None

Inventors:

NINOMIYA ITARU
KANAZAWA MASATO

Application Number:

JP2021025586A

Publication Date:

August 31, 2022

Filing Date:

February 19, 2021

Export Citation:

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Assignee:

UNIV NIIGATA

International Classes:

C12N5/0793; C12N5/0786

Attorney, Agent or Firm:

Sumio Tanai
Yasushi Matsunuma
Shu Oikawa

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