To obtain a medicinal composition stable during production and during preservation thereafter, and good in elutability by covering or mixing a specific amount of hydrophobic low melting-point material on or with an active ingredient, and carrying out a compression molding of the obtained particles with a goodly moldable material.
This medicinal composition is obtained by covering or mixing 0.01-1 pts.wt. hydrophobic low melting-point material (preferably having ≤100°C melting point, e.g. stearic acid) on or with 1 pts.wt. active ingredient (preferably an effective component of a medicine having the stability after the compression molding lowered from the stability before the compression molding when carrying out the compression molding, e.g. nicorandil), and carrying out a compression molding of the obtained particles with a goodly moldable material [preferably, the one capable of providing a tablet having ≥4 kg hardness when pressing 200 mg material under 2,000/cm2 pressure in a mold having 8 mm diameter, and ≤30 min corruption time in a corruption test of the pharmacopoeia of Japan (13 section), and being inert to a medicine, e.g. granulated lactic acid, and preferably added to a preparation at ≥10 wt.%] under 20-65 kg/mm2 pressure.
YAMADA NOBUO
SATO TOMOMI
