To obtain the subject preparation capable of also utilizing the colon as a site for absorbing a medicine, providing a stable concentration in the blood, and capable of extremely extending the absorbing time of the medicine by using the medicine, a specific additive and a high molecular material forming a hydrogel.
The objective preparation having the ability for nearly completely gelatinizing the preparation during the retention in the stomach and the small intestine at the upper part of the digestive tract, and having releasing ability of the medicine even at the colon at the lower part of the digestive tract comprises (A) one or more kinds of medicines (e.g. nicardipine hydrochloride), (B) one or more kinds of additives requiring ≥5 ml water for dissolving 1 g and for allowing the water to penetrate into the interior, (e.g. a polyethylene glycol, a polyvinylpyrrolidone and a D-sorbitol) and (C) a high molecular material capable of forming a hydrogel [capable of providing a high viscosity at the time of gelatinization, especially providing 1% aqueous solution having ≥1,000 cPs viscosity (at 25°C), e.g. a polyethylene oxide having ≥2,000,000 molecular weight].
NAKAJIMA HIROSHI
SAWADA TOYOHIRO
OKADA AKIRA
FUKUI MUNEO
JPS402053B | ||||
JPS63126825A | 1988-05-30 | |||
JPS62242613A | 1987-10-23 | |||
JPH02282322A | 1990-11-19 | |||
JPH0283316A | 1990-03-23 | |||
JPS5649314A | 1981-05-02 | |||
JPH06172160A | 1994-06-21 | |||
JPH05262767A | 1993-10-12 |
WO1992010169A1 | 1992-06-25 |