Title:
MEDICINAL COMPOSITION
Document Type and Number:
Japanese Patent JP2010031063
Kind Code:
A
Abstract:
To provide a new compound having action on the improvement of gastrointestinal motility function and suppressing occurrence of side effects.
There is provided the following new compound which is rich in binding affinity to serotonin receptor 4 (5HT4) and does not cause the onset of arteritis, clot formation or the like: 4-amino-5-chloro-2-methoxy-N-[(2S, 4S)-1-ethyl-2-hydroxymethyl-4-pyrrolidinyl]benzamide, or a metabolite of its acid additive salt of 4-amino-5-chloro-2-methoxy-N-[(2S, 4S)-2-hydroxymethyl-4-pyrrolidinyl]benzamide.
Inventors:
KITAJIMA AKIHIKO
KAMORITA OSAMU
OSAKO AKIHIRO
YANAGI TOSHIHARU
KAMORITA OSAMU
OSAKO AKIHIRO
YANAGI TOSHIHARU
Application Number:
JP2009263180A
Publication Date:
February 12, 2010
Filing Date:
November 18, 2009
Export Citation:
Assignee:
NAGASE CHEMTEX CORP
International Classes:
C07D207/14; A61K31/401; A61P1/14; A61P43/00
Domestic Patent References:
| JPH0517434A | 1993-01-26 |
Other References:
JPN7012003800; '４-ｈｙｄｒｏｘｙ-Ｌ-ｐｒｏｒｉｎｅ' ＴＨＥ Ｍｅｒｃｋ Ｉｎｄｅｘ １１ｔｈ ｅｄ． , 1989, ７６９ページ
JPN7012003801; '４-ヒドロキシプロリン' 化学辞典 第１版, 19950510, １１５２ページ, （株）東京化学同人
JPN7012003801; '４-ヒドロキシプロリン' 化学辞典 第１版, 19950510, １１５２ページ, （株）東京化学同人
Attorney, Agent or Firm:
Ryu Iwatani
Previous Patent: DEOXYNOJIRIMYCIN DERIVATIVE AND THEIR USE AS GLUCOSYLCERAMIDASE INHIBITOR
Next Patent: MANUFACTURING METHOD FOR HARD POLYURETHANE FOAM
Next Patent: MANUFACTURING METHOD FOR HARD POLYURETHANE FOAM