Title:
メラノサイト刺激ホルモン阻害剤
Document Type and Number:
Japanese Patent JP4273662
Kind Code:
B2
Abstract:
In the present specification is disclosed a melanocyte-stimulating hornone inhibitory composition which comprises, as the active ingredient, a di- or tripeptide derivative having a certain naphthyl group or the salts thereof, or a melanocyte-stimulating hormone inhibitory compound having a 50% inhibitory concentration of cAMP production (IC50) of 100 nM or less, which composition can prevent pigmentation, or can prevent, improve or recover from immune abnormality or immunodeficiency, or regulate body weight by appetite control, and also can be used as cosmetics or external preparations for the skin, and in addition, can be produced easily, and are excellent in the stability during storage.
Inventors:
Eiji Shiojiri
Takino Yoshinobu
Hiromi Nakajo
Sakamoto Izumi
Chichi Ichi
Yuzuru Eto
Keiji Iwasaki
Takino Yoshinobu
Hiromi Nakajo
Sakamoto Izumi
Chichi Ichi
Yuzuru Eto
Keiji Iwasaki
Application Number:
JP2000614275A
Publication Date:
June 03, 2009
Filing Date:
April 25, 2000
Export Citation:
Assignee:
AJINOMOTO CO.,LTD.
International Classes:
C07K5/08; A61K8/64; C07K5/087; C07K5/097; A61K38/00
Other References:
J. Med. Chem.,1995年 7月21日,Vol.38, No.15,p.2922-2924
J. Am. Chem. Soc.,1994年,Vol.116, No.23,p.10412-10425
Proc. Natl. Acad. Sci. USA.,1995年 3月28日,Vol.92, No.7,p.2894-2898
Monatshefte Chem.,1996年,Vol.127, No.10,p.1081-1097
J. Med. Chem.,1994年12月23日,Vol.37, No.26,p.4430-4437
Tetrahedron: Asymmetry,1995年,Vol.6, No.12,p.3039-3045
J. Am. Chem. Soc.,1994年,Vol.116, No.23,p.10412-10425
Proc. Natl. Acad. Sci. USA.,1995年 3月28日,Vol.92, No.7,p.2894-2898
Monatshefte Chem.,1996年,Vol.127, No.10,p.1081-1097
J. Med. Chem.,1994年12月23日,Vol.37, No.26,p.4430-4437
Tetrahedron: Asymmetry,1995年,Vol.6, No.12,p.3039-3045
Attorney, Agent or Firm:
Masao Shimokoshi