Title:
CCR2受容体アンタゴニストとしてのメルカプトイミダゾール
Document Type and Number:
Japanese Patent JP2008509201
Kind Code:
A
Abstract:
The present invention relates to a compound of formula (I) a N-oxide, a pharmaceutically acceptable addition salt, a quaternary amine and a stereochemically isomeric form thereof, wherein R1 represents hydrogen, C1-6alkyl, C3-7cycloalkyl, C1-6alkyloxyC1-6alkyl, di(C1-6alkyl)aminoC1-6alkyl, aryl or heteroaryl; each R2 independently represents halo, C1-6alkyl, C1-6alkyloxy, C1-6alkylthio, polyhaloC1-6alkyl, polyhaloC1-6alkyloxy, cyano, aminocarbonyl, amino, mono- or di(C1-4alkyl)amino, nitro, aryl or aryloxy; R3 represents cyano, C(-O)-O-R5, C(-O)-NR6aR6b or C(-O)-R7; or a cyclic ring system; R4 represents hydrogen or C1-6alkyl; n is 1, 2, 3, 4 or 5; R10 represents hydrogen, C1-6alkyl, C1-6alkylcarbonyl, C1-6alkyloxycarbonyl, arylcarbonyl, heteroarylcarbonyl, -C(-O)-NH-R5, -C(-S)-NH-R5 or -S(-O)2-R5. The invention also relates to processes for preparing the compounds of formula (I), their use as CCR2 antagonists and pharmaceutical compositions comprising them.
Inventors:
Van Lomen, Guy Rosalia Eugene
Bex, Gustav Maria
Bex, Gustav Maria
Application Number:
JP2007525305A
Publication Date:
March 27, 2008
Filing Date:
August 10, 2005
Export Citation:
Assignee:
JANSSEN PHARMACEUTICA NAAMLOZE VENNOOTSCHAP
International Classes:
C07D233/90; A61K31/4164; A61K31/4178; A61K31/422; A61K31/4245; A61K31/4439; A61K31/454; A61K31/496; A61K31/506; A61K31/5377; A61P29/00; A61P43/00; C07D401/12; C07D403/12; C07D405/12; C07D413/12
Attorney, Agent or Firm:
Patent business corporation Odashima patent office
Heikichi Odashima
Heikichi Odashima