MESSENGER RIBONUCLEIC ACIDS FOR ENHANCING IMMUNE RESPONSES AND METHODS OF USE THEREOF

Title:

MESSENGER RIBONUCLEIC ACIDS FOR ENHANCING IMMUNE RESPONSES AND METHODS OF USE THEREOF

Document Type and Number:

Japanese Patent JP2022184924

Kind Code:

A

Abstract:

To provide additional effective factors that enhance immune responses to antigens of interest.SOLUTION: Provided is isolated mRNAs encoding a polypeptide that enhances immune responses to an antigen(s) of interest, such as polypeptides that activate Type I interferon pathway signaling or NFκB signaling, including mRNAs comprising one or more modified nucleobase. Provided also is methods of using the same, for example, for enhancing immune responses when administered with an antigen(s) of interest, e.g., to stimulate anti-cancer immune responses or anti-pathogen immune responses.SELECTED DRAWING: None

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Inventors:

Juan, Eric E-Chun
Tse, Jee-Wah
Iacovelli, Jared
McKinney, Christine
Hopson, Kristen

Application Number:

JP2022143786A

Publication Date:

December 13, 2022

Filing Date:

September 09, 2022

Export Citation:

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Assignee:

ModernaTX,Inc.

International Classes:

C12N15/12; A61K9/14; A61K9/51; A61K31/7105; A61K31/7115; A61K31/712; A61K39/002; A61K39/02; A61K39/12; A61K39/395; A61K45/00; A61K47/18; A61K47/22; A61K47/24; A61K47/28; A61K47/34; A61K48/00; A61P37/04; A61P43/00; C07K14/47; C07K16/28

Attorney, Agent or Firm:

Yamato Kento
Norifumi Tomita
Fumio Inai
Manami Sasakura

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