Title:
ビタミンD誘導体の中間体として使用しうる化合物の製造方法
Document Type and Number:
Japanese Patent JP4233504
Kind Code:
B2
Abstract:
The object of the present invention is to provide vitamin D derivatives that have excellent physiological activities as medicines, particularly as therapeutic agents for skin diseases such as psoriasis, and that have a reduced hypercalcemic effect. The present invention provides a vitamin D derivative of Formula (1): wherein X represents an oxygen atom or a sulfur atom; m represents a number of 1 to 3; R1 and R2 each represent a hydrogen atom or an alkyl group; R4 and R5 each represent a hydrogen atom or a hydroxyl group, etc.; R3 represents -YR8, etc.; R6 represents a hydrogen atom, etc.; and R7 represents a hydrogen atom, etc.
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Inventors:
Kazumi Morikawa
Masayuki Omori
Kazuki Shimizu
Akira Kawase
Takeshi Emura
Masayuki Omori
Kazuki Shimizu
Akira Kawase
Takeshi Emura
Application Number:
JP2004265562A
Publication Date:
March 04, 2009
Filing Date:
September 13, 2004
Export Citation:
Assignee:
Chugai Pharmaceutical Co., Ltd.
International Classes:
C07J5/00; C07J7/00; A61K31/592; A61K31/593; A61P3/02; A61P17/00; C07B61/00; C07C235/06; C07C401/00; C07D295/185; C07F7/18; C07J1/00; C07J9/00; C07J75/00
Domestic Patent References:
| JP8503471A |
Other References:
FOLDES, R.S.- et al.,Palladium-catalyzed homogeneous coupling reactions of steroids with organostannanes,Steroids,1995年,Volume 60, Issue 12,Pages 812-816
CACCHI, S. et al.,Palladium-catalysed hydroxycarbonylation of vinyl and aryl triflates: a novel method for one-carbon homologation of ketones to α,β-unsaturated carboxylic acid derivatives,Tetrahedron Letters,1985年,Volume 26, Issue 8,Pages 1109-1112
CACCHI, S. et al.,Palladium-catalysed hydroxycarbonylation of vinyl and aryl triflates: a novel method for one-carbon homologation of ketones to α,β-unsaturated carboxylic acid derivatives,Tetrahedron Letters,1985年,Volume 26, Issue 8,Pages 1109-1112
Attorney, Agent or Firm:
Kazuo Shamoto
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Takashi Nakata
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Takashi Nakata