Title:
METHOD OF CONSTRUCTING DISPLAY LIBRARY OF GENETIC PACKAGE FOR MEMBER OF DIVERSE FAMILY OF PEPTIDES
Document Type and Number:
Japanese Patent JP2011135893
Kind Code:
A
Abstract:
To provide methods useful in constructing libraries that collectively display members of diverse families of peptides, polypeptides, or proteins, and the libraries produced using those methods.
As for methods of cleaving single-stranded nucleic acids at selected locations, the cleaved nucleic acids encodes, at least in part, the peptides, polypeptides, or proteins displayed on the genetic packages of the libraries. The genetic packages are filamentous phage or phagemids. The peptides, polypeptide, or proteins identified by such screening are provided. Also, any sequences that may be deleterious to expression are removed from the amplified DNA before cloning and displaying.
Inventors:
LADNER ROBERT C
COHEN EDWARD HIRSCH
NASTRI HORACIO GABRIEL
ROOKEY KRISTIN L
HOET RENE
COHEN EDWARD HIRSCH
NASTRI HORACIO GABRIEL
ROOKEY KRISTIN L
HOET RENE
Application Number:
JP2011044525A
Publication Date:
July 14, 2011
Filing Date:
March 01, 2011
Export Citation:
Assignee:
DYAX CORP
International Classes:
C12N15/09; C07K14/47; C07K16/18; C12N15/10; C12N15/66; C12Q1/68; C40B40/02; C40B50/06
Domestic Patent References:
| JP2000500647A | 2000-01-25 | |||
| JP2000500647A | 2000-01-25 |
Foreign References:
| US5962272A | 1999-10-05 | |||
| US5962271A | 1999-10-05 | |||
| WO1997008320A1 | 1997-03-06 | |||
| WO1997020923A1 | 1997-06-12 | |||
| WO1997049809A1 | 1997-12-31 | |||
| WO1997008320A1 | 1997-03-06 | |||
| WO1996035781A1 | 1996-11-14 | |||
| US5962272A | 1999-10-05 | |||
| US5962271A | 1999-10-05 | |||
| WO1997020923A1 | 1997-06-12 | |||
| WO1997049809A1 | 1997-12-31 |
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JPN6010069299; Ａｎａｌｙｔｉｃａｌ Ｂｉｏｃｈｅｍｉｓｔｒｙ， １９８９， Ｖｏｌ．１７７， ｐｐ．１２０-１２４
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JPN5002028666; ＰＯＤＨＡＪＳＫＡ Ａ Ｊ ＳＺＹＢＡＬＳＫＩ Ｗ: ＧＥＮＥ Ｖ４０Ｎ２-３, 1985, Ｐ１７５-１８２
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JPN6010069299; Ａｎａｌｙｔｉｃａｌ Ｂｉｏｃｈｅｍｉｓｔｒｙ， １９８９， Ｖｏｌ．１７７， ｐｐ．１２０-１２４
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Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita
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