Title:
METHOD FOR DETECTING HUMAN T-CELL LEUKEMIA VIRUS HBZ PROTEIN
Document Type and Number:
Japanese Patent JP2016114360
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide means capable of sensitively detecting or quantifying HBZ (HTLV-1 basic leucine zipper factor) protein which plays an important role in the onset of an HTLV-1 related disease.SOLUTION: A detection reagent of HBZ protein contains at least one type of antibody selected from the group consisting of an antibody specifically binding to peptide composed of an amino acid sequence represented by SEQ ID NO:4, an antibody specifically binding to peptide composed of an amino acid sequence represented by SEQ ID NO:5, and an antibody specifically binding to peptide composed of an amino acid sequence represented by SEQ ID NO:6. A diagnostic drug of an HTLV-1 related disease contains at least two types of the antibodies. A method for detecting an HTLV-1 related disease includes the steps of: (1) bringing a blood sample derived from a subject and the antibody into contact to form a composite body of HBZ protein contained in the blood sample and the antibody; and (2) detecting HBZ protein in the composite body formed in the step (1).SELECTED DRAWING: None
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Inventors:
SAITO MINETERU
SHIOHAMA YASUO
SHIOHAMA YASUO
Application Number:
JP2014250359A
Publication Date:
June 23, 2016
Filing Date:
December 10, 2014
Export Citation:
Assignee:
KAWASAKI GAKUEN
International Classes:
G01N33/574; C07K16/10; C12N15/02; C12N15/09; G01N33/543; G01N33/577
Other References:
高橋良明、外３名: "HTLV-1 basic leucine zipper factor(HBZ)抗原に対するモノクローナル抗体の作製とHBZ抗原検出系及び定量系", 第６１回日本ウイルス学会学術集会・総会プログラム・抄録集, vol. Vol.61st, JPN6018029323, 2013, JP, pages Page.358,P1-108
M.SAITO: "Molecular Analysis of Human T Cell Leukemia Virus Type-1 (HTLV-1) HBZ Gene in the Pathogenesis of HT", ノバルティス科学振興財団 財団年報, vol. Vol.24, JPN6018029325, 2012, pages 9 - 11
M.SAITO: "Molecular Analysis of Human T Cell Leukemia Virus Type-1 (HTLV-1) HBZ Gene in the Pathogenesis of HT", ノバルティス科学振興財団 財団年報, vol. Vol.24, JPN6018029325, 2012, pages 9 - 11
Attorney, Agent or Firm:
Takashima Ichi
Kyoko Doi
Mitsunori Kamata
Yaeko Tamura
Murata Miyuki
Junzo Koike
Hirofumi Toma
Kyoko Doi
Mitsunori Kamata
Yaeko Tamura
Murata Miyuki
Junzo Koike
Hirofumi Toma