METHOD FOR DETERMINING AGGLUTINATION

Title:

METHOD FOR DETERMINING AGGLUTINATION

Document Type and Number:

Japanese Patent JP2016121994

Kind Code:

A

Abstract:

PROBLEM TO BE SOLVED: To provide a method for determining agglutination of a biological liquid by measuring a change in hydrodynamic resistance of the biological liquid flowing through a microfluidic channel of a microfluidic device.SOLUTION: A method for determining agglutination of a biological liquid by measuring a change in hydrodynamic resistance of the biological liquid flowing through a microfluidic channel of a microfluidic device comprises the steps of: a) calibrating the microfluidic device using a calibrated value of hydrodynamic resistance of a known biological liquid concerning the presence and absence of agglutination; b) filling a microfluidic reaction channel 5 with a hydrophobic continuous liquid phase (continuous phase); c) introducing a first reference droplet into the microfluidic reaction channel; d) causing the first reference droplet to flow through the microfluidic reaction channel; e) measuring the time of flow of the first reference droplet through a measurement section 5a; f) introducing a sequence of test droplets after introducing a second reference droplet into the channel; g) causing the second reference droplet and the sequence of test droplet to flow through the microfluidic reaction channel; h) measuring the time of flow of the second reference droplet through the measurement section 5a in the presence of the test droplets; i) calculating hydrodynamic resistance of the sequence of test droplets; and j)determining agglutination of the biological liquid by comparing the hydrodynamic resistance with the a plurality of calibrated values.SELECTED DRAWING: Figure 1

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Inventors:

SYLWIA MAKULSKA

Application Number:

JP2015233621A

Publication Date:

July 07, 2016

Filing Date:

November 30, 2015

Export Citation:

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Assignee:

GEOMOBILE SP Z O O
SYLWIA MAKULSKA
ROBERT RAJEVSKI
MAREK SMOLSKI

International Classes:

G01N33/86; G01N33/53; G01N37/00

Attorney, Agent or Firm:

Longhua International Patent Service Corporation

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