Title:
鏡像異性富化されたシクロプロピルアラニン誘導体の調製方法
Document Type and Number:
Japanese Patent JP2004509940
Kind Code:
A
Abstract:
Disclosed are processes for the preparation of enantiomerically-enriched cyclopropylalanine derivatives by the hydrogenation of certain enamides in the presence of a catalyst comprising a transition metal and a substantially enantiomerically-pure bis-phosphine catalyst and certain novel enamide ester compounds which are intermediates in the processes. The processes include novel 2-step and 3-step processes for the preparation of enantiomerically-enriched cyclopropylalanine derivatives. The two-step process comprises the steps of reacting cyclopropanecarboxaldehyde with a substituted phosphorylglycine to afford an enamide ester which then is hydrogenated in the presence of a catalyst comprising a transition metal and a substantially enantiomerically-pure bis-phosphine catalyst. The three-step process comprises the steps of forming an azlactone from an N-acylglycine and cyclopropanecarboxaldehyde, converting the azlactone to the aforesaid enamide which then is hydrogenated in the presence of a catalyst comprising a transition metal and a substantially enantiomerically-pure bis-phosphine catalyst.
More Like This:
Inventors:
Devenham, Sheryl Davis
Boaz, Nail Warren
Boaz, Nail Warren
Application Number:
JP2002531081A
Publication Date:
April 02, 2004
Filing Date:
September 28, 2001
Export Citation:
Assignee:
EASTMAN CHEMICAL COMPANY
International Classes:
C07B53/00; C07B61/00; C07C231/10; C07C231/12; C07C231/18; C07C233/47; C07C233/48; C07C233/84; C07C233/86; B01J31/24; C07C269/00; C07C269/06; C07C271/22; C07D263/42; C07F9/40; C07C233/87; (IPC1-7): C07C231/12; B01J31/24; C07C233/48; C07C233/84; C07C269/06; C07C271/22
Attorney, Agent or Firm:
Takashi Ishida
Jun Tsuruta
Koji Takeuchi
Masaya Nishiyama
Higuchi Souji
Jun Tsuruta
Koji Takeuchi
Masaya Nishiyama
Higuchi Souji