METHOD FOR PRODUCING OPTICALLY ACTIVE SULFOXIDE DERIVATIVE

WIPO Patent Application WO/2016/076160

A1

[Problem] To provide a method for producing an industrially preferred optically active sulfoxide derivative. [Solution] A method for producing an optically active sulfoxide derivative represented by general formula (1), the method characterized by comprising reacting a sulfide derivative represented by general formula (2) with an oxidizing agent in the presence of a chiral catalyst which is a metal-chiral-ligand complex including a metal compound and a compound represented by general formula (3) as a chiral ligand, and in the presence of a benzoic acid compound represented by general formula (4).

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YASUMURA SHINGO (JP)
MUKAWA SHIGEYUKI (JP)

PCT/JP2015/080973

May 19, 2016

November 03, 2015

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IHARA CHEMICAL IND CO (JP)
KUMIAI CHEMICAL INDUSTRY CO (JP)

C07C315/02; C07C317/22; C07C319/20; C07C321/04; C07B53/00; C07B61/00

WO2013157229A1

2013-10-24

JP5616519B1	2014-10-29
JP2015160813A	2015-09-07

JULIEN LEGROS ET AL.: "Investigations on the Iron-Catalyzed Asymmetric Sulfide Oxidation", CHEMISTRY - A EUROPEAN JOURNAL, vol. 11, 2005, pages 1086 - 1092
QINGLE ZENG ET AL.: "Vanadium-catalyzed enantioselective sulfoxidation and concomitant, highly efficient kinetic resolution provide high enantioselectivity and acceptable yields of sulfoxides", ADVANCED SYNTHESIS & CATALYSIS, vol. 347, no. 15, 2005, pages 1933 - 1936

SHA Takuho (JP)
謝 卓峰 (JP)

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