Title:
1-フエニル-3-ジメチルアミノ-プロパン化合物の製造方法
Document Type and Number:
Japanese Patent JP4846552
Kind Code:
B2
Abstract:
3-Phenyl-N,N-dimethyl-propylamine derivs. of formula (I) and their isomers and acid-addn. salts are new; X = H, OH, F, Cl or 2-4C alkanoyloxy; R1 = 1-4C alkyl; R2 = H or 1-4C alkyl; R3 = H or 1-4C n-alkyl; or CR2R3 = 4-7C cycloalkylidene; R4 and R5 = gps. defined as follows: when R5 = H, R4 = meta-O-Z, meta-S-C1-3-alkyl, meta-Cl, meta-F, meta-CR9R10R11, ortho-OH, ortho-O-C2-3-alkyl, para-F or para-CR9R10R11; or when R5 = Cl, F, OH or O-C1-3-alkyl in the para position, R4 = Cl, F, OH or O-C1-3-alkyl in the meta position; or R4+R5 = 3,4-OCH=CH or 3,4-OCH=CHO-; Z = H, 1-3C-alkyl, PO(O-C1-4-alkyl)2, CO(OC1-5-alkyl), CONH-C6H4-(C1-3-alkyl), CO-C6H4-R7; R7 = ortho-OCOC1-3-alkyl or meta- or para-CH2N(R8)2; R8 = 1-4C-alkyl or 4-morpholino; R9, R10 and R11 = H or F.
Inventors:
Helmut Bushman
Wolfgang Scheutraussberger
Elmar Friedrichs
Wolfgang Scheutraussberger
Elmar Friedrichs
Application Number:
JP2006342354A
Publication Date:
December 28, 2011
Filing Date:
December 20, 2006
Export Citation:
Assignee:
Grunenthal Gesellschaft Mito Beschlenktel Haftung
International Classes:
C07C213/00; A61K31/135; A61K31/138; A61K31/215; A61K31/27; A61K31/34; A61K31/343; A61P25/04; A61P29/00; C07C209/68; C07C211/27; C07C211/29; C07C211/30; C07C213/06; C07C213/08; C07C215/30; C07C215/54; C07C215/62; C07C217/62; C07C217/66; C07C217/72; C07C217/74; C07C219/06; C07C219/22; C07C225/10; C07C237/40; C07C271/58; C07C319/20; C07C323/32; C07C323/36; C07C323/37; C07D307/79; C07D307/81; C07D319/18; C07B53/00
Other References:
Biokhimiya Rastenii,1973年,Vol.1,281-285
Soobshcheniya Akademii Nauk Gruzinskoi SSR,1972年,Vol.68, No.2,341-344
Soobshcheniya Akademii Nauk Gruzinskoi SSR,1972年,Vol.68, No.2,341-344
Attorney, Agent or Firm:
Mitsufumi Esaki
Blacksmith
Blacksmith