Title:
METHOD FOR PRODUCING CARBAPENEMS
Document Type and Number:
Japanese Patent JP2002338572
Kind Code:
A
Abstract:
To provide a method for industrially advantageously producing carbapenems.
This method for producing the compound (VIII) in the formula comprises reacting a compound (I) (R1 is a protective group of OH) in the formula with (i) N,N'-carbonyldiimidazole, or (ii) a halogenated carbonic acid ester and an imidazole in the presence of a base, reacting the product with an inorganic salt and R2OOCCH2COOH (R2 is a protective group of COOH), further reacting the obtained product with an azide compound, reacting the resultant product with an acid, subjecting the obtained product to a ring-closing reaction, and reacting the ring-closed product with R3OH (R3 is an acyl group) or a reactive derivative thereof.
Inventors:
FUJIWARA YOSHITAKA
AKIYAMA TOSHIHIRO
NISHIMURA SHUICHI
HATANO TOSHIMITSU
KUMAGAI TOSHIO
SHIMIZU HISASHI
AKIYAMA TOSHIHIRO
NISHIMURA SHUICHI
HATANO TOSHIMITSU
KUMAGAI TOSHIO
SHIMIZU HISASHI
Application Number:
JP2002081966A
Publication Date:
November 27, 2002
Filing Date:
July 08, 1992
Export Citation:
Assignee:
TAKEDA CHEMICAL INDUSTRIES LTD
WYETH LEDERLE JAPAN LTD
WYETH LEDERLE JAPAN LTD
International Classes:
C07D477/00; C07B61/00; C07F9/6561; (IPC1-7): C07D477/00; C07F9/6561
Attorney, Agent or Firm:
Shuichi Takahashi