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Title:
METHOD FOR PRODUCING D-MANNOSAMINE DERIVATIVE
Document Type and Number:
Japanese Patent JP3703509
Kind Code:
B2
Abstract:

PURPOSE: To obtain a D-mannosamine derivative useful as an intermediate for neuraminic acid by protecting the hydroxyl group of a specific talopyranose compound, treating the protected compound with a base, protecting the produced hydroxyl group, deprotecting the first hydroxyl group, oxidizing the product, treating the oxidation product with hydroxyamine and subsequently reducing the treated product.
CONSTITUTION: The method for producing the D-mannosamine deirvative of formula V used as the precursor of D-mannosamine useful as a synthetic intermediate for neuraminic acid comprises protecting the hydroxyl group of 1, 6:3,4- dianhydro-β-D-talopyranose of formula I with a 1-ethoxyethyl group, etc., treating the protected product with a base, protecting the hydroxyl group of the produced β-D-mannopyranose derivative of formula II (R2 is the hydroxyl group-protecting group) with a phenylmethyl group, etc., removing the hydroxyl group-protecting group of R2 from the protected compound, oxidizing the produced compound of formula III (R1 is the hydroxyl group-protecting group), treating the oxidation product with hydroxyamine or its derivative, and subsequently reducing the produced oxime compound of formula IV.


Inventors:
Takahashi, Takashi
Yamada, Haruo
Application Number:
JP1994000220327
Publication Date:
October 05, 2005
Filing Date:
September 14, 1994
Export Citation:
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Assignee:
KURARAY CO LTD
International Classes:
C07H1/00; C07H3/10; C07H5/04; C07H5/06; (IPC1-7): C07H5/04; C07H1/00; C07H5/06
Domestic Patent References:
JP5448778A
Foreign References: