Title:
3-オキソ-4-アザ-5α-アンドロスタン化合物の選択的製造方法
Document Type and Number:
Japanese Patent JP4226552
Kind Code:
B2
Abstract:
This invention relates to a method for selectively preparing the 3-oxo-4-aza-5¥á-androstane compound which is used as an intermediate of finasteride by heating 3-oxo-4-aza-5-androstene in a mixture of formic acid and an alkanediol in the presence of zinc.
Inventors:
Mon, Yun Ho
Li, Kyun-Iku
Park, gassun
Park, Chulu-Hyun
Li, Je-Chul
Li, Gwang-Sun
Chang, Yun-Kill
Li, Kyun-Iku
Park, gassun
Park, Chulu-Hyun
Li, Je-Chul
Li, Gwang-Sun
Chang, Yun-Kill
Application Number:
JP2004528926A
Publication Date:
February 18, 2009
Filing Date:
August 13, 2003
Export Citation:
Assignee:
Hammi Farm. Seeo., LDT.
International Classes:
C07J73/00; C07D221/18; C07J75/00; C07B61/00
Domestic Patent References:
| JP193600A | ||||
| JP61257996A |
Foreign References:
| US5693809 | ||||
| WO1993023039A1 | ||||
| WO2002046207A1 |
Other References:
RASMUSSON, G.H. et al.,Azasteroids: structure-activity relationships for inhibition of 5.alpha.-reductase and of androgen receptor binding ,J. Med. Chem.,1986年,Vol.29, No.11,p.2298-2315
Solomons, W.E. et al.,Syntehsis and antimicrobial properties of 7beta-amino-4-aza-5alpha-androstane and derivatives,Journal of Pharmaceutical Sciences,1974年,Vol.63, No.1,p.19-23
Solomons, W.E. et al.,Syntehsis and antimicrobial properties of 7beta-amino-4-aza-5alpha-androstane and derivatives,Journal of Pharmaceutical Sciences,1974年,Vol.63, No.1,p.19-23
Attorney, Agent or Firm:
Takehiko Suzue
Satoshi Kono
Makoto Nakamura
Kurata Masatoshi
Takashi Mine
Yoshihiro Fukuhara
Sadao Muramatsu
Ryo Hashimoto
Satoshi Kono
Makoto Nakamura
Kurata Masatoshi
Takashi Mine
Yoshihiro Fukuhara
Sadao Muramatsu
Ryo Hashimoto