Title:
H因子結合部位に基づく免疫原性組成物およびワクチンの開発方法
Document Type and Number:
Japanese Patent JP2007533645
Kind Code:
A
Abstract:
The present invention relates to an immunogenic composition. More particularly, the present invention is a composition directed to eliciting an immune response to at least one covalent binding site of myristate (SEQ ID NOS: 1-3) on the HIV matrix protein. The present invention contemplates three categories of embodiments: protein or protein fragments (SEQ ID NO: 1), messenger RNA, or DNA/RNA (SEQ ID NOS:2-3). DNA/RNA compositions may be either naked or recombinant. The present invention further contemplates use with a variety of immune stimulants.
Inventors:
Nelson M. Carp
Application Number:
JP2006536893A
Publication Date:
November 22, 2007
Filing Date:
October 25, 2004
Export Citation:
Assignee:
NK Research LLC
International Classes:
A61K39/21; A61K9/00; A61K9/06; A61K9/08; A61K9/14; A61K9/20; A61K9/48; A61K9/70; A61K9/72; A61K31/736; A61K38/00; A61K38/46; A61K39/02; A61K39/12; A61K39/39; A61K45/00; A61P31/18; A61P43/00; C07K14/155; C07K14/16; C12N7/00; C12N7/06; C12Q1/70; A61K39/00; A61K47/12; C12N1/19; C12N1/21; C12N15/09
Domestic Patent References:
| JPH10510246A | 1998-10-06 |
Foreign References:
| WO2000058438A2 | 2000-10-05 |
Other References:
JPN6010047709, Ｈｏｃｋｎｅｌｌ ＰＫ ｅｔ ａｌ．, "Ｅｘｐｒｅｓｓｉｏｎ ｏｆ ｈｕｍａｎ ｉｍｍｕｎｏｄｅｆｉｃｉｅｎｃｙ ｖｉｒｕｓ ｔｙｐｅ １ ｇｐ１２０ ｆｒｏｍ ｈｅｒｐｅｓ ｓｉｍｐｌｅｘ ｖｉｒｕｓ ｔｙｐｅ １−ｄｅｒｉｖｅｄ ａｍｐ", Ｊ Ｖｉｒｏｌ．, 200206, ７６巻１１号, ｐｐ．５５６５−５５８０
JPN6010047711, Ｓｔｏｉｂｅｒ Ｈ ｅｔ ａｌ．, "Ｈｕｍａｎ ｃｏｍｐｌｅｍｅｎｔ ｐｒｏｔｅｉｎｓ Ｃ３ｂ， Ｃ４ｂ， ｆａｃｔｏｒ Ｈ ａｎｄ ｐｒｏｐｅｒｄｉｎ ｒｅａｃｔ ｗｉｔｈ ｓｐｅｃｉｆｉｃ ｓｉｔｅｓ ｉｎ ｇｐ１２０ ａｎｄ ｇｐ", Ｉｍｍｕｎｏｂｉｏｌｏｇｙ．, 199506, １９３巻１号, ｐｐ．９８−１１３
JPN6010047712, Ｓｔｏｉｂｅｒ Ｈ ｅｔ ａｌ．, "Ｅｆｆｉｃｉｅｎｔ ｄｅｓｔｒｕｃｔｉｏｎ ｏｆ ｈｕｍａｎ ｉｍｍｕｎｏｄｅｆｉｃｉｅｎｃｙ ｖｉｒｕｓ ｉｎ ｈｕｍａｎ ｓｅｒｕｍ ｂｙ ｉｎｈｉｂｉｔｉｎｇ ｔｈｅ ｐｒｏｔｅｃｔｉｖｅ ａｃ", Ｊ Ｅｘｐ Ｍｅｄ．, 199601, １８３巻１号, ｐｐ．３０７−３１０
JPN6010047714, Ｃａｉｒｎｓ ＪＳ ａｎｄ Ｓａｒｖｅｒ Ｎ．, "Ｎｅｗ ｖｉｒａｌ ｖｅｃｔｏｒｓ ｆｏｒ ＨＩＶ ｖａｃｃｉｎｅ ｄｅｌｉｖｅｒｙ．", ＡＩＤＳ Ｒｅｓ Ｈｕｍ Ｒｅｔｒｏｖｉｒｕｓｅｓ．, 19981120, １４巻１７号, ｐｐ．１５０１−１５０８
JPN6010047716, Ｋｏｕｐ ＲＡ ｅｔ ａｌ．, "Ａｎｔｉｇｅｎｉｃ ｓｐｅｃｉｆｉｃｉｔｙ ｏｆ ａｎｔｉｂｏｄｙ−ｄｅｐｅｎｄｅｎｔ ｃｅｌｌ−ｍｅｄｉａｔｅｄ ｃｙｔｏｔｏｘｉｃｉｔｙ ｄｉｒｅｃｔｅｄ ａｇａｉｎｓｔ ｈｕｍａｎ ｉｍｍｕｎｏ", Ｊ Ｖｉｒｏｌ．, 198902, ６３巻２号, ｐｐ．５８４−５９０
JPN6010047717, Ｈｏｎｄａ Ｍ ｅｔ ａｌ．, "Ｐｒｏｔｅｃｔｉｖｅ ｉｍｍｕｎｅ ｒｅｓｐｏｎｓｅｓ ｉｎｄｕｃｅｄ ｂｙ ｓｅｃｒｅｔｉｏｎ ｏｆ ａ ｃｈｉｍｅｒｉｃ ｓｏｌｕｂｌｅ ｐｒｏｔｅｉｎ ｆｒｏｍ ａ ｒｅｃｏｍｂｉｎａｎｔ Ｍｙ", Ｐｒｏｃ Ｎａｔｌ Ａｃａｄ Ｓｃｉ Ｕ Ｓ Ａ．, 19951107, ９２巻２３号, ｐｐ．１０６９３−１０６９７
JPN6010047719, Ｇｕｚｍａｎ ＣＡ ｅｔ ａｌ．, "Ａｔｔｅｎｕａｔｅｄ Ｌｉｓｔｅｒｉａ ｍｏｎｏｃｙｔｏｇｅｎｅｓ ｃａｒｒｉｅｒ ｓｔｒａｉｎｓ ｃａｎ ｄｅｌｉｖｅｒ ａｎ ＨＩＶ−１ ｇｐ１２０ Ｔ ｈｅｌｐｅｒ ｅｐｉｔｏｐｅ ｔｏ ＭＨＣ", Ｅｕｒ Ｊ Ｉｍｍｕｎｏｌ．, 199806, ２８巻６号, ｐｐ．１８０７−１８１４
JPN6010047721, Ｍａｎｃａ Ｆ．, "Ｇａｌａｃｔｏｓｅ ｒｅｃｅｐｔｏｒｓ ａｎｄ ｐｒｅｓｅｎｔａｔｉｏｎ ｏｆ ＨＩＶ ｅｎｖｅｌｏｐｅ ｇｌｙｃｏｐｒｏｔｅｉｎ ｔｏ ｓｐｅｃｉｆｉｃ ｈｕｍａｎ Ｔ ｃｅｌｌｓ．", Ｊ Ｉｍｍｕｎｏｌ．, 19920401, １４８巻７号, ｐｐ．２２７８−２２８２
JPN6010047723, Ｗｉｎｋｅｌｓｔｅｉｎ ＪＡ ａｎｄ Ｔｏｍａｓｚ Ａ, "Ａｃｔｉｖａｔｉｏｎ ｏｆ ｔｈｅ Ａｌｔｅｒｎａｔｉｖｅ Ｃｏｍｐｌｅｍｅｎｔ Ｐａｔｈｗａｙ ｂｙ Ｐｎｅｕｍｏｃｏｃｃａｌ Ｃｅｌｌ Ｗａｌｌ Ｔｅｉｃｈｏｉｃ Ａｃｉｄ１", Ｔｈｅ Ｊｏｕｒｎａｌ ｏｆ Ｉｍｍｕｎｏｌｏｇｙ，, 1978, １２０巻, ｐｐ．１７４−１７８
JPN6010047725, Ａｒａ Ｙ ｅｔ ａｌ．, "Ｚｙｍｏｓａｎ ｅｎｈａｎｃｅｓ ｔｈｅ ｉｍｍｕｎｅ ｒｅｓｐｏｎｓｅ ｔｏ ＤＮＡ ｖａｃｃｉｎｅ ｆｏｒ ｈｕｍａｎ ｉｍｍｕｎｏｄｅｆｉｃｉｅｎｃｙ ｖｉｒｕｓ ｔｙｐｅ−１ ｔｈｒｏｕｇｈ", Ｉｍｍｕｎｏｌｏｇｙ．, 200105, １０３巻１号, ｐｐ．９８−１０５
JPN6010047727, Ｓａｈｕ Ａ ｅｔ ａｌ．, "Ｓｐｅｃｉｆｉｃｉｔｙ ｏｆ ｔｈｅ ｔｈｉｏｅｓｔｅｒ−ｃｏｎｔａｉｎｉｎｇ ｒｅａｃｔｉｖｅ ｓｉｔｅ ｏｆ ｈｕｍａｎ Ｃ３ ａｎｄ ｉｔｓ ｓｉｇｎｉｆｉｃａｎｃｅ ｔｏ ｃｏｍｐｌｅｍｅｎｔ", Ｂｉｏｃｈｅｍ Ｊ．, 19940901, ３０２巻, ｐｐ．：４２９−４３６
JPN6010047729, Ｇｏｗｄａ ＤＣ ｅｔ ａｌ．, "Ｉｍｍｕｎｏｒｅａｃｔｉｖｉｔｙ ａｎｄ ｆｕｎｃｔｉｏｎ ｏｆ ｏｌｉｇｏｓａｃｃｈａｒｉｄｅｓ ｉｎ ｃｏｂｒａ ｖｅｎｏｍ ｆａｃｔｏｒ．", Ｊ Ｉｍｍｕｎｏｌ．, 19940315, １５２巻６号, ｐｐ．２９７７−２９８６
JPN6010047731, Ｆｉｓｈｅｌｓｏｎ Ｚ ａｎｄ Ｍｕｌｌｅｒ−Ｅｂｅｒｈａｒｄ ＨＪ, "Ｃ３ ｃｏｎｖｅｒｔａｓｅ ｏｆ ｈｕｍａｎ ｃｏｍｐｌｅｍｅｎｔ： ｅｎｈａｎｃｅｄ ｆｏｒｍａｔｉｏｎ ａｎｄ ｓｔａｂｉｌｉｔｙ ｏｆ ｔｈｅ ｅｎｚｙｍｅ ｇｅｎｅｒａｔｅｄ ｗｉｔｈ ｎｉｃ", Ｔｈｅ Ｊｏｕｒｎａｌ ｏｆ Ｉｍｍｕｎｏｌｏｇｙ, 198212, １２９巻６号, ｐｐ．２６０３−２６０７
JPN6010047732, Ｍｅｒｉ Ｓ ａｎｄ Ｐａｎｇｂｕｒｎ ＭＫ．, "Ｄｉｓｃｒｉｍｉｎａｔｉｏｎ ｂｅｔｗｅｅｎ ａｃｔｉｖａｔｏｒｓ ａｎｄ ｎｏｎａｃｔｉｖａｔｏｒｓ ｏｆ ｔｈｅ ａｌｔｅｒｎａｔｉｖｅ ｐａｔｈｗａｙ ｏｆ ｃｏｍｐｌｅｍｅｎｔ： ｒｅｇｕｌａ", Ｐｒｏｃ Ｎａｔｌ Ａｃａｄ Ｓｃｉ Ｕ Ｓ Ａ．, 199005, ８７巻１０号, ｐｐ．３９８２−３９８６
JPN6010047733, Ｗｅｉｌｅｒ ＪＭ ｅｔ ａｌ．, "Ｍｏｄｕｌａｔｉｏｎ ｏｆ ｔｈｅ ｆｏｒｍａｔｉｏｎ ｏｆ ｔｈｅ ａｍｐｌｉｆｉｃａｔｉｏｎ ｃｏｎｖｅｒｔａｓｅ ｏｆ ｃｏｍｐｌｅｍｅｎｔ， Ｃ３ｂ， Ｂｂ， ｂｙ ｎａｔｉｖｅ ａｎｄ ｃｏ", Ｊ Ｅｘｐ Ｍｅｄ．, 19780201, １４７巻２号, ｐｐ．４０９−４２１
JPN6010047735, Ｃｈａｎｇ ＬＣ ｅｔ ａｌ．, "Ｌｏｗ ｍｏｌｅｃｕｌａｒ ｗｅｉｇｈｔ ｐｒｏｔａｍｉｎｅ ａｓ ｎｏｎｔｏｘｉｃ ｈｅｐａｒｉｎ／ｌｏｗ ｍｏｌｅｃｕｌａｒ ｗｅｉｇｈｔ ｈｅｐａｒｉｎ ａｎｔｉｄｏｔｅ （ＩＩＩ）： Ｐｒｅｌ", ＡＡＰＳ ＰｈａｒｍＳｃｉ．, 200109, ３巻３号, ｐｐ．２４−３１
JPN6010047711, Ｓｔｏｉｂｅｒ Ｈ ｅｔ ａｌ．, "Ｈｕｍａｎ ｃｏｍｐｌｅｍｅｎｔ ｐｒｏｔｅｉｎｓ Ｃ３ｂ， Ｃ４ｂ， ｆａｃｔｏｒ Ｈ ａｎｄ ｐｒｏｐｅｒｄｉｎ ｒｅａｃｔ ｗｉｔｈ ｓｐｅｃｉｆｉｃ ｓｉｔｅｓ ｉｎ ｇｐ１２０ ａｎｄ ｇｐ", Ｉｍｍｕｎｏｂｉｏｌｏｇｙ．, 199506, １９３巻１号, ｐｐ．９８−１１３
JPN6010047712, Ｓｔｏｉｂｅｒ Ｈ ｅｔ ａｌ．, "Ｅｆｆｉｃｉｅｎｔ ｄｅｓｔｒｕｃｔｉｏｎ ｏｆ ｈｕｍａｎ ｉｍｍｕｎｏｄｅｆｉｃｉｅｎｃｙ ｖｉｒｕｓ ｉｎ ｈｕｍａｎ ｓｅｒｕｍ ｂｙ ｉｎｈｉｂｉｔｉｎｇ ｔｈｅ ｐｒｏｔｅｃｔｉｖｅ ａｃ", Ｊ Ｅｘｐ Ｍｅｄ．, 199601, １８３巻１号, ｐｐ．３０７−３１０
JPN6010047714, Ｃａｉｒｎｓ ＪＳ ａｎｄ Ｓａｒｖｅｒ Ｎ．, "Ｎｅｗ ｖｉｒａｌ ｖｅｃｔｏｒｓ ｆｏｒ ＨＩＶ ｖａｃｃｉｎｅ ｄｅｌｉｖｅｒｙ．", ＡＩＤＳ Ｒｅｓ Ｈｕｍ Ｒｅｔｒｏｖｉｒｕｓｅｓ．, 19981120, １４巻１７号, ｐｐ．１５０１−１５０８
JPN6010047716, Ｋｏｕｐ ＲＡ ｅｔ ａｌ．, "Ａｎｔｉｇｅｎｉｃ ｓｐｅｃｉｆｉｃｉｔｙ ｏｆ ａｎｔｉｂｏｄｙ−ｄｅｐｅｎｄｅｎｔ ｃｅｌｌ−ｍｅｄｉａｔｅｄ ｃｙｔｏｔｏｘｉｃｉｔｙ ｄｉｒｅｃｔｅｄ ａｇａｉｎｓｔ ｈｕｍａｎ ｉｍｍｕｎｏ", Ｊ Ｖｉｒｏｌ．, 198902, ６３巻２号, ｐｐ．５８４−５９０
JPN6010047717, Ｈｏｎｄａ Ｍ ｅｔ ａｌ．, "Ｐｒｏｔｅｃｔｉｖｅ ｉｍｍｕｎｅ ｒｅｓｐｏｎｓｅｓ ｉｎｄｕｃｅｄ ｂｙ ｓｅｃｒｅｔｉｏｎ ｏｆ ａ ｃｈｉｍｅｒｉｃ ｓｏｌｕｂｌｅ ｐｒｏｔｅｉｎ ｆｒｏｍ ａ ｒｅｃｏｍｂｉｎａｎｔ Ｍｙ", Ｐｒｏｃ Ｎａｔｌ Ａｃａｄ Ｓｃｉ Ｕ Ｓ Ａ．, 19951107, ９２巻２３号, ｐｐ．１０６９３−１０６９７
JPN6010047719, Ｇｕｚｍａｎ ＣＡ ｅｔ ａｌ．, "Ａｔｔｅｎｕａｔｅｄ Ｌｉｓｔｅｒｉａ ｍｏｎｏｃｙｔｏｇｅｎｅｓ ｃａｒｒｉｅｒ ｓｔｒａｉｎｓ ｃａｎ ｄｅｌｉｖｅｒ ａｎ ＨＩＶ−１ ｇｐ１２０ Ｔ ｈｅｌｐｅｒ ｅｐｉｔｏｐｅ ｔｏ ＭＨＣ", Ｅｕｒ Ｊ Ｉｍｍｕｎｏｌ．, 199806, ２８巻６号, ｐｐ．１８０７−１８１４
JPN6010047721, Ｍａｎｃａ Ｆ．, "Ｇａｌａｃｔｏｓｅ ｒｅｃｅｐｔｏｒｓ ａｎｄ ｐｒｅｓｅｎｔａｔｉｏｎ ｏｆ ＨＩＶ ｅｎｖｅｌｏｐｅ ｇｌｙｃｏｐｒｏｔｅｉｎ ｔｏ ｓｐｅｃｉｆｉｃ ｈｕｍａｎ Ｔ ｃｅｌｌｓ．", Ｊ Ｉｍｍｕｎｏｌ．, 19920401, １４８巻７号, ｐｐ．２２７８−２２８２
JPN6010047723, Ｗｉｎｋｅｌｓｔｅｉｎ ＪＡ ａｎｄ Ｔｏｍａｓｚ Ａ, "Ａｃｔｉｖａｔｉｏｎ ｏｆ ｔｈｅ Ａｌｔｅｒｎａｔｉｖｅ Ｃｏｍｐｌｅｍｅｎｔ Ｐａｔｈｗａｙ ｂｙ Ｐｎｅｕｍｏｃｏｃｃａｌ Ｃｅｌｌ Ｗａｌｌ Ｔｅｉｃｈｏｉｃ Ａｃｉｄ１", Ｔｈｅ Ｊｏｕｒｎａｌ ｏｆ Ｉｍｍｕｎｏｌｏｇｙ，, 1978, １２０巻, ｐｐ．１７４−１７８
JPN6010047725, Ａｒａ Ｙ ｅｔ ａｌ．, "Ｚｙｍｏｓａｎ ｅｎｈａｎｃｅｓ ｔｈｅ ｉｍｍｕｎｅ ｒｅｓｐｏｎｓｅ ｔｏ ＤＮＡ ｖａｃｃｉｎｅ ｆｏｒ ｈｕｍａｎ ｉｍｍｕｎｏｄｅｆｉｃｉｅｎｃｙ ｖｉｒｕｓ ｔｙｐｅ−１ ｔｈｒｏｕｇｈ", Ｉｍｍｕｎｏｌｏｇｙ．, 200105, １０３巻１号, ｐｐ．９８−１０５
JPN6010047727, Ｓａｈｕ Ａ ｅｔ ａｌ．, "Ｓｐｅｃｉｆｉｃｉｔｙ ｏｆ ｔｈｅ ｔｈｉｏｅｓｔｅｒ−ｃｏｎｔａｉｎｉｎｇ ｒｅａｃｔｉｖｅ ｓｉｔｅ ｏｆ ｈｕｍａｎ Ｃ３ ａｎｄ ｉｔｓ ｓｉｇｎｉｆｉｃａｎｃｅ ｔｏ ｃｏｍｐｌｅｍｅｎｔ", Ｂｉｏｃｈｅｍ Ｊ．, 19940901, ３０２巻, ｐｐ．：４２９−４３６
JPN6010047729, Ｇｏｗｄａ ＤＣ ｅｔ ａｌ．, "Ｉｍｍｕｎｏｒｅａｃｔｉｖｉｔｙ ａｎｄ ｆｕｎｃｔｉｏｎ ｏｆ ｏｌｉｇｏｓａｃｃｈａｒｉｄｅｓ ｉｎ ｃｏｂｒａ ｖｅｎｏｍ ｆａｃｔｏｒ．", Ｊ Ｉｍｍｕｎｏｌ．, 19940315, １５２巻６号, ｐｐ．２９７７−２９８６
JPN6010047731, Ｆｉｓｈｅｌｓｏｎ Ｚ ａｎｄ Ｍｕｌｌｅｒ−Ｅｂｅｒｈａｒｄ ＨＪ, "Ｃ３ ｃｏｎｖｅｒｔａｓｅ ｏｆ ｈｕｍａｎ ｃｏｍｐｌｅｍｅｎｔ： ｅｎｈａｎｃｅｄ ｆｏｒｍａｔｉｏｎ ａｎｄ ｓｔａｂｉｌｉｔｙ ｏｆ ｔｈｅ ｅｎｚｙｍｅ ｇｅｎｅｒａｔｅｄ ｗｉｔｈ ｎｉｃ", Ｔｈｅ Ｊｏｕｒｎａｌ ｏｆ Ｉｍｍｕｎｏｌｏｇｙ, 198212, １２９巻６号, ｐｐ．２６０３−２６０７
JPN6010047732, Ｍｅｒｉ Ｓ ａｎｄ Ｐａｎｇｂｕｒｎ ＭＫ．, "Ｄｉｓｃｒｉｍｉｎａｔｉｏｎ ｂｅｔｗｅｅｎ ａｃｔｉｖａｔｏｒｓ ａｎｄ ｎｏｎａｃｔｉｖａｔｏｒｓ ｏｆ ｔｈｅ ａｌｔｅｒｎａｔｉｖｅ ｐａｔｈｗａｙ ｏｆ ｃｏｍｐｌｅｍｅｎｔ： ｒｅｇｕｌａ", Ｐｒｏｃ Ｎａｔｌ Ａｃａｄ Ｓｃｉ Ｕ Ｓ Ａ．, 199005, ８７巻１０号, ｐｐ．３９８２−３９８６
JPN6010047733, Ｗｅｉｌｅｒ ＪＭ ｅｔ ａｌ．, "Ｍｏｄｕｌａｔｉｏｎ ｏｆ ｔｈｅ ｆｏｒｍａｔｉｏｎ ｏｆ ｔｈｅ ａｍｐｌｉｆｉｃａｔｉｏｎ ｃｏｎｖｅｒｔａｓｅ ｏｆ ｃｏｍｐｌｅｍｅｎｔ， Ｃ３ｂ， Ｂｂ， ｂｙ ｎａｔｉｖｅ ａｎｄ ｃｏ", Ｊ Ｅｘｐ Ｍｅｄ．, 19780201, １４７巻２号, ｐｐ．４０９−４２１
JPN6010047735, Ｃｈａｎｇ ＬＣ ｅｔ ａｌ．, "Ｌｏｗ ｍｏｌｅｃｕｌａｒ ｗｅｉｇｈｔ ｐｒｏｔａｍｉｎｅ ａｓ ｎｏｎｔｏｘｉｃ ｈｅｐａｒｉｎ／ｌｏｗ ｍｏｌｅｃｕｌａｒ ｗｅｉｇｈｔ ｈｅｐａｒｉｎ ａｎｔｉｄｏｔｅ （ＩＩＩ）： Ｐｒｅｌ", ＡＡＰＳ ＰｈａｒｍＳｃｉ．, 200109, ３巻３号, ｐｐ．２４−３１
Attorney, Agent or Firm:
Masatake Shiga
Takashi Watanabe
Yasuhiko Murayama
Shinya Mitsuhiro
Takashi Watanabe
Yasuhiko Murayama
Shinya Mitsuhiro