Title:
炎症及びアポトーシスに関係する方法及び試薬
Document Type and Number:
Japanese Patent JP2006509724
Kind Code:
A
Abstract:
The present invention relates to, among other embodiments, protein complexes which include tumor necrosis factor alpha (TNF-alpha) and/or tumor necrosis factor alpha receptor (TNFR). Preferably, the complexes comprise at least one polypeptide selected from the group consisting of: NF-kappaB activating kinase (NAK), RasGAP3, TRCP1, and TRCP2. The present invention further provides assays of identifying a compound for modulating the stability and activity of the complex. Also provided are methods of modulating apoptosis and inflammation, as well as treating TNF-alpha related diseases.
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Inventors:
Kuai, Jun
Lyrin, Lee Lin
Wouters, Joseph, Elle.
Nickberg, Elliott
Lyrin, Lee Lin
Wouters, Joseph, Elle.
Nickberg, Elliott
Application Number:
JP2004526400A
Publication Date:
March 23, 2006
Filing Date:
August 01, 2003
Export Citation:
Assignee:
Wyeth
International Classes:
C07K19/00; A61K38/00; A61K39/395; A61K45/00; A61P1/00; A61P1/04; A61P11/06; A61P19/02; A61P29/00; A61P31/04; A61P31/12; A61P33/00; A61P35/00; A61P37/00; A61P43/00; C07K14/47; C07K14/525; C07K14/715; C07K14/82; C07K16/18; C07K16/24; C07K16/28; C07K16/32; C07K16/40; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N9/12; C12N15/09; C12P21/02; C12Q1/02; C12Q1/48; G01N33/15; G01N33/50
Attorney, Agent or Firm:
Junji Endo