Title:
大環状化合物を形成するための方法、組成物および装置
Document Type and Number:
Japanese Patent JP2008504225
Kind Code:
A
Abstract:
This invention relates to methods, compositions, and apparatuses for producing macrocyclic compounds. First, one or more reactants are provided in a reaction medium, which are capable of forming the macrocyclic compound through a desired reaction pathway that includes at least cyclization, and which are further capable of forming undesired oligomers through a undesired reaction pathway that includes undesirable oligomerization. Oligomerization of such reactions in the reaction medium is modulated to reduce formation of undesired oligomers and/or to reduce separation of the undesired oligomers from the reaction medium, relative to a corresponding unmodulated oligomerization reaction, thereby maximizing yields of the macrocyclic compound. The macrocyclic compound so formed is then recovered from the reaction medium. Preferably, the macrocyclic compound spontaneously separates from the reaction medium via phase separation. More preferably, the macrocyclic compound spontaneous precipitates from the reaction medium and therefore can be easily recovered by simple filtration.
Inventors:
Johnson, Thomas, Yee.
Fowler, Billy, Tee.
Fowler, Billy, Tee.
Application Number:
JP2006553366A
Publication Date:
February 14, 2008
Filing Date:
February 17, 2005
Export Citation:
Assignee:
Johnson, Thomas, Yee.
Fowler, Billy, Tee.
Fowler, Billy, Tee.
International Classes:
C07B37/10; C07C2/72; C07C13/70; C07C37/20; C07C39/17; C07D291/08; C07D313/00; C07D323/00; C07D341/00; C07D487/22; C07D493/22; C07D513/22; C07F5/02; C07F9/6581; C07K1/02; C07K2/00; C07B61/00
Domestic Patent References:
| JP2000191574A | 2000-07-11 | |||
| JP2000016955A | 2000-01-18 |
Attorney, Agent or Firm:
Yoshiyuki Inaba
Shinji Oga
Toshifumi Onuki
Shinji Oga
Toshifumi Onuki