Title:
癌を治療するための方法及び組成物
Document Type and Number:
Japanese Patent JP2010501575
Kind Code:
A
Abstract:
Methods and compositions for treating cancer are described herein. More particularly, the methods for treating cancer comprise administering a 17α-hydroxylase/C17,20-lyase inhibitor, such as abiraterone acetate (i.e., 3β-acetoxy-17-(3-pyridyl) androsta-5, 16-diene), in combination with at least one additional therapeutic agent such as an anti-cancer agent or a steroid. Furthermore, disclosed are compositions comprising a 17α-hydroxylase/C17,20-lyase inhibitor, and at least one additional therapeutic agent, such as an anti-cancer agent or a steroid.
Inventors:
Alan H. Auerbakow
Arie S. Berludegrun
Arie S. Berludegrun
Application Number:
JP2009525647A
Publication Date:
January 21, 2010
Filing Date:
August 23, 2007
Export Citation:
Assignee:
Kuogal Biotechnology, Inc.
International Classes:
A61K31/58; A61K31/136; A61K31/167; A61K31/277; A61K31/337; A61K31/573; A61K38/00; A61K38/04; A61K45/00; A61P35/00; A61P43/00; C07J43/00
Other References:
JPN6010055819, ＡＴＴＡＲＤ，Ｇ． ｅｔ ａｌ, "Ｓｅｌｅｃｔｉｖｅ ｂｌｏｃｋａｄｅ ｏｆ ａｎｄｒｏｇｅｎｉｃ ｓｔｅｒｏｉｄ ｓｙｎｔｈｅｓｉｓ ｂｙ ｎｏｖｅｌ ｌｙａｓｅ ｉｎｈｉｂｉｔｏｒｓ ａｓ ａ ｔｈｅｒａｐｅｕｔｉｃ ｓｔｒａｔｅ", ＢＪＵ Ｉｎｔ, 2005, Ｖｏｌ．９６， Ｎｏ．９, ｐ．１２４１−６
JPN5009012042, Ｏ’ＤＯＮＮＥＬＬ Ａ, ＢＲＩＴＩＳＨ ＪＯＵＲＮＡＬ ＯＦ ＣＡＮＣＥＲ, 20040614, Ｖ９０ Ｎ１２, Ｐ２３１７−２３２５, GB
JPN5009012043, ＭＡＤＡＮ ＲＡＶＩ Ａ, ＩＤＲＵＧＳ, 2006, Ｖ９ Ｎ１, Ｐ４９−５５, GB, ＣＵＲＲＥＮＴ ＤＲＵＧＳ ＬＴＤ
JPN7010003049, ＣＯＬＬＩＮＳ，Ｒ． ｅｔ ａｌ, "Ａ ｓｙｓｔｅｍａｔｉｃ ｒｅｖｉｅｗ ｏｆ ｔｈｅ ｅｆｆｅｃｔｉｖｅｎｅｓｓ ｏｆ ｄｏｃｅｔａｘｅｌ ａｎｄ ｍｉｔｏｘａｎｔｒｏｎｅ ｆｏｒ ｔｈｅ ｔｒｅａｔｍｅｎｔ ｏｆ ｍｅｔａｓｔａｔ", Ｂｒ Ｊ Ｃａｎｃｅｒ, 2006, Ｖｏｌ．９５， Ｎｏ．４, ｐ．４５７−６２
JPN7010003050, ＰＥＴＲＹＬＡＫ，Ｄ．Ｐ．, "Ｆｕｔｕｒｅ ｄｉｒｅｃｔｉｏｎｓ ｉｎ ｔｈｅ ｔｒｅａｔｍｅｎｔ ｏｆ ａｎｄｒｏｇｅｎ−ｉｎｄｅｐｅｎｄｅｎｔ ｐｒｏｓｔａｔｅ ｃａｎｃｅｒ", Ｕｒｏｌｏｇｙ, 2005, Ｖｏｌ．６５， Ｎｏ．６ Ｓｕｐｐｌ, ｐ．８−１２
JPN7010003051, ＯＵＤＡＲＤ，Ｓ． ｅｔ ａｌ, "［Ｐｒｏｓｔａｔｅ ｃａｎｃｅｒ： ｕｐｄａｔｅ］", Ｂｕｌｌ Ｃａｎｃｅｒ, 2005, Ｖｏｌ．９２， Ｎｏ．１０, ｐ．８６５−７３
JPN5009012042, Ｏ’ＤＯＮＮＥＬＬ Ａ, ＢＲＩＴＩＳＨ ＪＯＵＲＮＡＬ ＯＦ ＣＡＮＣＥＲ, 20040614, Ｖ９０ Ｎ１２, Ｐ２３１７−２３２５, GB
JPN5009012043, ＭＡＤＡＮ ＲＡＶＩ Ａ, ＩＤＲＵＧＳ, 2006, Ｖ９ Ｎ１, Ｐ４９−５５, GB, ＣＵＲＲＥＮＴ ＤＲＵＧＳ ＬＴＤ
JPN7010003049, ＣＯＬＬＩＮＳ，Ｒ． ｅｔ ａｌ, "Ａ ｓｙｓｔｅｍａｔｉｃ ｒｅｖｉｅｗ ｏｆ ｔｈｅ ｅｆｆｅｃｔｉｖｅｎｅｓｓ ｏｆ ｄｏｃｅｔａｘｅｌ ａｎｄ ｍｉｔｏｘａｎｔｒｏｎｅ ｆｏｒ ｔｈｅ ｔｒｅａｔｍｅｎｔ ｏｆ ｍｅｔａｓｔａｔ", Ｂｒ Ｊ Ｃａｎｃｅｒ, 2006, Ｖｏｌ．９５， Ｎｏ．４, ｐ．４５７−６２
JPN7010003050, ＰＥＴＲＹＬＡＫ，Ｄ．Ｐ．, "Ｆｕｔｕｒｅ ｄｉｒｅｃｔｉｏｎｓ ｉｎ ｔｈｅ ｔｒｅａｔｍｅｎｔ ｏｆ ａｎｄｒｏｇｅｎ−ｉｎｄｅｐｅｎｄｅｎｔ ｐｒｏｓｔａｔｅ ｃａｎｃｅｒ", Ｕｒｏｌｏｇｙ, 2005, Ｖｏｌ．６５， Ｎｏ．６ Ｓｕｐｐｌ, ｐ．８−１２
JPN7010003051, ＯＵＤＡＲＤ，Ｓ． ｅｔ ａｌ, "［Ｐｒｏｓｔａｔｅ ｃａｎｃｅｒ： ｕｐｄａｔｅ］", Ｂｕｌｌ Ｃａｎｃｅｒ, 2005, Ｖｏｌ．９２， Ｎｏ．１０, ｐ．８６５−７３
Attorney, Agent or Firm:
Toru Ishikawa